T
Taishi Hashiguchi
Researcher at Hokkaido University
Publications - 23
Citations - 702
Taishi Hashiguchi is an academic researcher from Hokkaido University. The author has contributed to research in topics: Steatohepatitis & Hepatocellular carcinoma. The author has an hindex of 11, co-authored 20 publications receiving 552 citations.
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Journal ArticleDOI
Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis
Eric Lefebvre,Graeme Moyle,Ran Reshef,Lee P. Richman,Melanie A. Thompson,Feng Hong,Hsin-l Chou,Taishi Hashiguchi,Craig Plato,Dominic Poulin,Toni Richards,Hiroyuki Yoneyama,Helen E. Jenkins,Grushenka Wolfgang,Scott L. Friedman +14 more
TL;DR: Cenicriviroc displayed potent anti-inflammatory and antifibrotic activity in a range of animal fibrosis models, supporting human testing for fibrotic diseases.
Journal ArticleDOI
Faulty Initiation of Proteoglycan Synthesis Causes Cardiac and Joint Defects
Sevjidmaa Baasanjav,Lihadh Al-Gazali,Taishi Hashiguchi,Shuji Mizumoto,Bjoern Fischer,Denise Horn,Dominik Seelow,Bassam R. Ali,Samir A. A. Aziz,RD Langer,Ahmed Ahmed A H. Saleh,Christian Becker,Gudrun Nürnberg,Vincent Cantagrel,Joseph G. Gleeson,Delphine Gomez,Jean-Baptiste Michel,Sigmar Stricker,Tom H. Lindner,Peter Nürnberg,Kazuyuki Sugahara,Stefan Mundlos,Katrin Hoffmann +22 more
TL;DR: The study shows that reduced GlcAT-I activity impairs skeletal as well as heart development and results in variable combinations of heart malformations, including mitral valve prolapse, ventricular septal defect, and bicuspid aortic valve.
Journal ArticleDOI
Involvement of highly sulfated chondroitin sulfate in the metastasis of the Lewis lung carcinoma cells.
Fuchuan Li,Fuchuan Li,Gerdy B. ten Dam,Sengottuvelan Murugan,Shuhei Yamada,Shuhei Yamada,Taishi Hashiguchi,Shuji Mizumoto,Kayoko Oguri,Minoru Okayama,Toin H. van Kuppevelt,Kazuyuki Sugahara,Kazuyuki Sugahara +12 more
TL;DR: Results suggest that the E-unit-containing epitopes are involved in the metastatic process and a potential target for the diagnosis and treatment of malignant tumors.
Journal ArticleDOI
Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis.
Kenji Suzuki,Somasundaram Arumugam,Junji Yokoyama,Yusuke Kawauchi,Yutaka Honda,Hiroki Sato,Yutaka Aoyagi,Shuji Terai,Kazuichi Okazaki,Yasuo Suzuki,Shuji Mizumoto,Kazuyuki Sugahara,Kazuyuki Sugahara,Raja Atreya,Markus F. Neurath,Kenichi Watanabe,Taishi Hashiguchi,Hiroyuki Yoneyama,Hitoshi Asakura +18 more
TL;DR: It is demonstrated that blockade CHST15 represses colonic fibrosis and enhances MH partly though reversing EMT pathway, illustrating a novel therapeutic opportunity to refractory and fibrotic lesions in IBD.
Journal Article
Characterization of non-alcoholic steatohepatitis-derived hepatocellular carcinoma as a human stratification model in mice.
Kazuki Takakura,Shigeo Koido,Masato Fujii,Taishi Hashiguchi,Yuichiro Shibazaki,Hiroyuki Yoneyama,Hiroaki Katagi,Mikio Kajihara,Takeyuki Misawa,Sadamu Homma,Toshifumi Ohkusa,Hisao Tajiri +11 more
TL;DR: It is shown that the recently-reported, non-alcoholic steatohepatitis-derived HCC model (STAM model) is the first murine model in which the concept of human stratification is applicable by demonstrating the following features: at least 4 detectable tumor nodules and no visible metastasis.