T
Takashi Hirasawa
Researcher at Tokyo Institute of Technology
Publications - 92
Citations - 3665
Takashi Hirasawa is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Corynebacterium glutamicum & Saccharomyces cerevisiae. The author has an hindex of 30, co-authored 87 publications receiving 3337 citations. Previous affiliations of Takashi Hirasawa include Osaka University & Mitsui Chemicals.
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Journal ArticleDOI
Multiple high-throughput analyses monitor the response of E. coli to perturbations.
Nobuyoshi Ishii,Kenji Nakahigashi,Tomoya Baba,Tomoya Baba,Martin Robert,Tomoyoshi Soga,Akio Kanai,Takashi Hirasawa,Miki Naba,Kenta Hirai,Aminul Hoque,Pei Yee Ho,Yuji Kakazu,Kaori Sugawara,Saori Igarashi,Satoshi Harada,Takeshi Masuda,Naoyuki Sugiyama,Takashi Togashi,Miki Hasegawa,Yuki Takai,Katsuyuki Yugi,Kazuharu Arakawa,Nayuta Iwata,Yoshihiro Toya,Yoichi Nakayama,Takaaki Nishioka,Takaaki Nishioka,Kazuyuki Shimizu,Kazuyuki Shimizu,Hirotada Mori,Hirotada Mori,Masaru Tomita +32 more
TL;DR: E. coli seems to use complementary strategies that result in a metabolic network robust against perturbations, and actively regulated enzyme levels to maintain a stable metabolic state in response to changes in growth rate.
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Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae.
Katsunori Yoshikawa,Tadamasa Tanaka,Chikara Furusawa,Keisuke Nagahisa,Takashi Hirasawa,Hiroshi Shimizu +5 more
TL;DR: The growth behavior of all available single gene deletion strains of budding yeast under ethanol stress revealed that the growth of 446 deletion strains under stress induced by 8% ethanol was defective, and the genes and functional categories identified might provide clues to improving ethanol stress tolerance among yeast cells.
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Identification of target genes conferring ethanol stress tolerance to Saccharomyces cerevisiae based on DNA microarray data analysis.
Takashi Hirasawa,Katsunori Yoshikawa,Yuki Nakakura,Keisuke Nagahisa,Chikara Furusawa,Yoshio Katakura,Hiroshi Shimizu,Suteaki Shioya +7 more
TL;DR: Results indicate that overexpression of the genes for trypophan biosynthesis increases the ethanol stress tolerance, and Tryptophan supplementation to culture and overexpressive of the tryptophan permease gene are also effective for the increase in ethanol stressolerance.
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Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae.
Katsunori Yoshikawa,Tadamasa Tanaka,Yoshihiro Ida,Chikara Furusawa,Takashi Hirasawa,Hiroshi Shimizu +5 more
TL;DR: Genome‐wide analyses enabled the extraction of the genes and identification of the functional categories for which genetic perturbation caused the change of growth behaviour, and identified several functional categories having fragility and robustness for cellular growth.
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Transcriptome analysis of parallel-evolved Escherichia coli strains under ethanol stress
Takaaki Horinouchi,Kuniyasu Tamaoka,Chikara Furusawa,Naoaki Ono,Shingo Suzuki,Takashi Hirasawa,Tetsuya Yomo,Hiroshi Shimizu +7 more
TL;DR: Genes related to iron ion metabolism were commonly up-regulated in the tolerant strains, which suggests the change in intracellular redox state during adaptive evolution.