Takeshi Matsumura

TL;DR: This paper showed that hyperglycaemia increases the production of reactive oxygen species inside cultured bovine aortic endothelial cells and that this increase in reactive oxygen can be prevented by an inhibitor of electron transport chain complex II, an uncoupler of oxidative phosphorylation, by uncoupling protein-1 and by manganese superoxide dismutase.

TL;DR: Results suggest that metformin normalizes hyperglycemia-induced mtROS production by induction of MnSOD and promotion of mitochondrial biogenesis through the activation of AMPK-PGC-1alpha pathway.

TL;DR: The data suggest for the first time that AMPK suppresses VSMC proliferation via cell cycle regulation by p53 upregulation and AMPK activation in VSMCs may be a therapoietic target for the prevention of vascular diseases.

TL;DR: Hyperglycemia independently increases 8-OHdG in patients with type 2 diabetes, and this biomarker is a useful biomarker of not only microvascular but also macrovascular complications in Patients withType 2 diabetes.

TL;DR: The results suggest that TNF-α increases mitochondrial ROS and activates ASK1 in Huh7 cells and that these T NF-α–induced phenomena contribute, at least in part, to impaired insulin signaling.