T
Tomoichiro Asano
Researcher at Hiroshima University
Publications - 232
Citations - 16536
Tomoichiro Asano is an academic researcher from Hiroshima University. The author has contributed to research in topics: Insulin resistance & Insulin receptor. The author has an hindex of 66, co-authored 221 publications receiving 15378 citations. Previous affiliations of Tomoichiro Asano include Teikyo University & Yamaguchi University.
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Journal ArticleDOI
Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy
Yutaka Matsui,Hiromitsu Takagi,Xueping Qu,Maha Abdellatif,Hideyuki Sakoda,Tomoichiro Asano,Beth Levine,Junichi Sadoshima,Junichi Sadoshima +8 more
TL;DR: The results suggest that, in the heart, ischemia stimulates autophagy through an AMPK-dependent mechanism, whereas ischemIA/reperfusion stimulates autophile through a Beclin 1–dependent but AM PK-independent mechanism.
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Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms
Junichi Miyazaki,Kimi Araki,Eiji Yamato,Hiroshi Ikegami,Tomoichiro Asano,Yoshikazu Shibasaki,Yoshitomo Oka,Ken Ichi Yamamura +7 more
TL;DR: The MIN6 cell line will be especially useful to analyze the molecular mechanisms by which beta cells regulate insulin secretion in response to extracellular glucose concentrations, and a possible role of GT isoforms in glucose sensing by beta cells is discussed.
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PI3K-mediated negative feedback regulation of IL-12 production in DCs
Taro Fukao,Masanobu Tanabe,Yasuo Terauchi,Takayuki Ota,Satoshi Matsuda,Tomoichiro Asano,Takashi Kadowaki,Tsutomu Takeuchi,Shigeo Koyasu +8 more
TL;DR: It is shown that phosphoinositide 3-kinase (PI3K) negatively regulates IL-12 synthesis by DCs, and an enhanced T helper type 1 (TH1) response was observed upon Leishmania major infection in PI3K−/− mice.
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Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets.
Hisamitsu Ishihara,Tomoichiro Asano,Katsunori Tsukuda,Hideki Katagiri,Kouichi Inukai,Motonobu Anai,Masatoshi Kikuchi,Yoshio Yazaki,J.-I. Miyazaki,Yoshitomo Oka +9 more
TL;DR: Glucose-stimulated insulin secretion, glucose transport, glucose phosphorylation and glucose utilization have been characterized in the insulinoma cell line MIN6, indicating that this cell line is an appropriate model for studying the mechanism of glucose- stimulated insulin secretion in pancreatic beta cells.
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Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase
Yasuo Terauchi,Yuki Tsuji,Shinobu Satoh,H. Minoura,Katsuhiko Murakami,Akira Okuno,Kouichi Inukai,Tomoichiro Asano,Yasushi Kaburagi,K Ueki,Hiromu Nakajima,Toshiaki Hanafusa,Yuji Matsuzawa,Hisahiko Sekihara,Yuxin Yin,Barrett Jc,Hideaki Oda,Takatoshi Ishikawa,Yasuo Akanuma,Issei Komuro,Misao Suzuki,Ken Ichi Yamamura,Tatsuhiko Kodama,Hidekazu Suzuki,Shigeo Koyasu,Shinichi Aizawa,Kazuyuki Tobe,Y. Fukui,Yoshio Yazaki,Takashi Kadowaki +29 more
TL;DR: This work provides the first direct evidence that PI3K and its regulatory subunit have a role in glucose homeostasis in vivo.