D
Daisuke Kukidome
Researcher at Kumamoto University
Publications - 31
Citations - 2419
Daisuke Kukidome is an academic researcher from Kumamoto University. The author has contributed to research in topics: Mitochondrial ROS & Reactive oxygen species. The author has an hindex of 18, co-authored 31 publications receiving 2190 citations. Previous affiliations of Daisuke Kukidome include University of Tokyo.
Papers
More filters
Journal ArticleDOI
Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells
Daisuke Kukidome,Takeshi Nishikawa,Kazuhiro Sonoda,Koujiro Imoto,Kazuo Fujisawa,Miyuki Yano,Hiroyuki Motoshima,Tetsuya Taguchi,Takeshi Matsumura,Eiichi Araki +9 more
TL;DR: Results suggest that metformin normalizes hyperglycemia-induced mtROS production by induction of MnSOD and promotion of mitochondrial biogenesis through the activation of AMPK-PGC-1alpha pathway.
Journal ArticleDOI
Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells: Potential Role in Diabetic Nephropathy
Shinsuke Kiritoshi,Takeshi Nishikawa,Kazuhiro Sonoda,Daisuke Kukidome,Takahumi Senokuchi,Tomoko Matsuo,Takeshi Matsumura,Hiroshi Tokunaga,Michael Brownlee,Eiichi Araki +9 more
TL;DR: The results suggest that hyperglycemia increases mitochondrial ROS production, resulting in NF-kappaB activation, COx-2 mRNA induction, COX-2 protein production, and PGE2 synthesis, which might contribute to the pathogenesis of diabetic nephropathy.
Journal ArticleDOI
Adenosine Monophosphate-Activated Protein Kinase Suppresses Vascular Smooth Muscle Cell Proliferation Through the Inhibition of Cell Cycle Progression
Motoyuki Igata,Hiroyuki Motoshima,Kaku Tsuruzoe,Kanou Kojima,Takeshi Matsumura,Tatsuya Kondo,Tetsuya Taguchi,Kazuhiko Nakamaru,Miyuki Yano,Daisuke Kukidome,K. Matsumoto,Tetsushi Toyonaga,Tomoichiro Asano,Takeshi Nishikawa,Eiichi Araki +14 more
TL;DR: The data suggest for the first time that AMPK suppresses VSMC proliferation via cell cycle regulation by p53 upregulation and AMPK activation in VSMCs may be a therapoietic target for the prevention of vascular diseases.
Journal ArticleDOI
Statins Activate Peroxisome Proliferator-Activated Receptor γ Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase-Dependent Cyclooxygenase-2 Expression in Macrophages
Miyuki Yano,Takeshi Matsumura,Takafumi Senokuchi,Norio Ishii,Yusuke Murata,Kayo Taketa,Hiroyuki Motoshima,Tetsuya Taguchi,Kazuhiro Sonoda,Daisuke Kukidome,Yoh Takuwa,Teruo Kawada,Michael Brownlee,Takeshi Nishikawa,Eiichi Araki +14 more
TL;DR: It is demonstrated that statins inhibited lipopolysaccharide-induced tumor necrosis factor α or monocyte chemoattractant protein-1 mRNA expression, and these effects by statins were abrogated by the PPARγ antagonist T0070907 or by small interfering RNA of PPARβ or PPARα.
Journal ArticleDOI
Evaluation of urinary 8-hydroxydeoxy-guanosine as a novel biomarker of macrovascular complications in type 2 diabetes
Takeshi Nishikawa,Takayuki Sasahara,Shinsuke Kiritoshi,Kazuhiro Sonoda,Takahumi Senokuchi,Tomoko Matsuo,Daisuke Kukidome,Nakayasu Wake,Takeshi Matsumura,Nobuhiro Miyamura,Michiharu Sakakida,Hideki Kishikawa,Eiichi Araki +12 more
TL;DR: Hyperglycemia independently increases 8-OHdG in patients with type 2 diabetes, and this biomarker is a useful biomarker of not only microvascular but also macrovascular complications in Patients withType 2 diabetes.