T
Takeshi Yamazaki
Researcher at Hiroshima University
Publications - 90
Citations - 2796
Takeshi Yamazaki is an academic researcher from Hiroshima University. The author has contributed to research in topics: Neuroprotection & Pregnenolone. The author has an hindex of 27, co-authored 90 publications receiving 2539 citations. Previous affiliations of Takeshi Yamazaki include University of Wisconsin-Madison & Tokyo Institute of Technology.
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Journal ArticleDOI
Adrenocortical zonation in humans under normal and pathological conditions
Koshiro Nishimoto,Ken Nakagawa,Dan Li,Takeo Kosaka,Mototsugu Oya,Shuji Mikami,Hirotaka Shibata,Hiroshi Itoh,Fumiko Mitani,Takeshi Yamazaki,Tadashi Ogishima,Makoto Suematsu,Kuniaki Mukai +12 more
TL;DR: Investigating the localization of CYP11B2 and -B1 in human adrenal specimens by using developed antibodies capable of distinguishing the two enzymes from each other revealed a variegated zonation with cell clusters constitutively expressing CYP 11B2, which may provide a pathological confirmatory diagnosis of adrenocortical adenomas.
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Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons.
Hideo Mukai,Tomokazu Tsurugizawa,Gen Murakami,Shiro Kominami,Hirotaka Ishii,Mari Ogiue-Ikeda,Norio Takata,Nobuaki Tanabe,A. Furukawa,Yasushi Hojo,Yuuki Ooishi,John H. Morrison,William G.M. Janssen,John A. Rose,Pierre Chambon,Shigeaki Kato,Shunsuke Izumi,Takeshi Yamazaki,Tetsuya Kimoto,Suguru Kawato +19 more
TL;DR: Two types of independent synaptic plasticity, long‐term depression and spinogenesis, were investigated, in response to 17β‐estradiol and agonists of estrogen receptors using hippocampal slices from adult male rats, and it was demonstrated that estradiol rapidly enhanced LTD not only in CA1 but also in CA3 and dentate gyrus.
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Regulation of cholesterol movement to mitochondrial cytochrome P450scc in steroid hormone synthesis
TL;DR: It is suggested that hormonal activation, through these factors, alters membrane structure around mitochondrial intermembrane contact sites, which also function to transfer ADP, phospholipids, and proteins to the inner mitochondria.
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Avian neurosteroids. I. Pregnenolone biosynthesis in the quail brain
TL;DR: The results suggest that the brain produces pregnenolone from cholesterol in adult male Japanese quails, and most accumulation of pregnanolone in the brain may be independent of the peripheral endocrine gland system.
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Pregnenolone, pregnenolone sulfate, and cytochrome P450 side-chain cleavage enzyme in the amphibian brain and their seasonal changes.
TL;DR: It is suggested that the amphibian brain possesses steroidogenic enzyme P450scc and produces pregnenolone and its sulfate ester, which may function well during the breeding and postbreeding active phases of the year in the seasonal breeder.