T
Tamara Alpermann
Researcher at Ludwig Maximilian University of Munich
Publications - 123
Citations - 6592
Tamara Alpermann is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 38, co-authored 123 publications receiving 5735 citations.
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Journal ArticleDOI
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
T Haferlach,Yasunobu Nagata,Vera Grossmann,Yusuke Okuno,Ulrike Bacher,Genta Nagae,Susanne Schnittger,Masashi Sanada,Ayana Kon,Tamara Alpermann,Kenichi Yoshida,Andreas Roller,Niroshan Nadarajah,Yuichi Shiraishi,Yusuke Shiozawa,Kenichi Chiba,Hirokazu Tanaka,H P Koeffler,Hans-Ulrich Klein,Martin Dugas,Hiroyuki Aburatani,Alexander Kohlmann,Satoru Miyano,Claudia Haferlach,Wolfgang Kern,Seishi Ogawa +25 more
TL;DR: Large-scale genetic and molecular profiling of multiple target genes is invaluable for subclassification and prognostication in MDS patients.
Journal ArticleDOI
Landscape Of Genetic Lesions In 944 Patients With Myelodysplastic Syndromes
Yasunobu Nagata,Vera Grossmann,Yusuke Okuno,Ulrike Bacher,Genta Nagae,Susanne Schnittger,Yusuke Shiozawa,Ayana Kon,Tamara Alpermann,Kenichi Yoshida,Masashi Sanada,Andreas Roller,Niroshan Nadarajah,Yuichi Shiraishi,H. Phillip Koeffler,Hans-Ulrich Klein,Martin Dugas,Kenichi Chiba,Hiroko Tanaka,Alexander Kohlmann,Satoru Miyano,Claudia Haferlach,Hiroyuki Aburatani,Wolfgang Kern,Seishi Ogawa,Torsten Haferlach +25 more
TL;DR: These results demonstrated that the mutation/deletion status of a set of genes could be used as variables independent of clinical parameters to build a clinically relevant prognostic score.
Journal ArticleDOI
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
Ayana Kon,Lee Yung Shih,Masashi Minamino,Masashi Sanada,Masashi Sanada,Yuichi Shiraishi,Yasunobu Nagata,Kenichi Yoshida,Yusuke Okuno,Masashige Bando,Ryuichiro Nakato,Shumpei Ishikawa,Shumpei Ishikawa,Aiko Sato-Otsubo,Genta Nagae,Aiko Nishimoto,Claudia Haferlach,Daniel Nowak,Yusuke Sato,Tamara Alpermann,Masao Nagasaki,Teppei Shimamura,Hiroko Tanaka,Kenichi Chiba,Ryo Yamamoto,Tomoyuki Yamaguchi,Makoto Otsu,Naoshi Obara,Mamiko Sakata-Yanagimoto,Tsuyoshi Nakamaki,Ken Ishiyama,Florian Nolte,Wolf-Karsten Hofmann,Shuichi Miyawaki,Shigeru Chiba,Hiraku Mori,Hiromitsu Nakauchi,H. Phillip Koeffler,H. Phillip Koeffler,Hiroyuki Aburatani,Torsten Haferlach,Katsuhiko Shirahige,Satoru Miyano,Seishi Ogawa,Seishi Ogawa +44 more
TL;DR: A role for compromised cohesin functions in myeloid leukemogenesis is suggested by the growth of leukemic cell lines harboring a mutation in RAD21 or having severely reduced expression of RAD21 and STAG2 being suppressed by forced expression of wild-type RAD21 (Kasumi-1 cells and MOLM-13 cells).
Journal ArticleDOI
SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)
Manja Meggendorfer,Andreas Roller,Torsten Haferlach,Christiane Eder,Frank Dicker,Vera Grossmann,Alexander Kohlmann,Tamara Alpermann,Kenichi Yoshida,Seishi Ogawa,H. Phillip Koeffler,H. Phillip Koeffler,Wolfgang Kern,Claudia Haferlach,Susanne Schnittger +14 more
TL;DR: The importance of SRSF2mut as new diagnostic marker in CMML is shown, with 93% of all patients with CMML carried at least 1 somatic mutation in 9 recurrently mutated genes.
Journal ArticleDOI
RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis
Susanne Schnittger,Frank Dicker,Wolfgang Kern,Nicole Wendland,Jana Sundermann,Tamara Alpermann,Claudia Haferlach,Torsten Haferlach +7 more
TL;DR: Multivariate analysis showed independent prognostic relevance for overall survival for RUNX1mut, FLT3-ITD, age, and white blood cell count, as well as of the high frequency of prognostically favorable NPM1mut and CEBPAmut in the RunX1wt group.