T
Tomoyuki Yamaguchi
Researcher at University of Tokyo
Publications - 63
Citations - 5698
Tomoyuki Yamaguchi is an academic researcher from University of Tokyo. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 24, co-authored 60 publications receiving 4911 citations.
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Journal ArticleDOI
Frequent pathway mutations of splicing machinery in myelodysplasia
Kenichi Yoshida,Masashi Sanada,Yuichi Shiraishi,Daniel Nowak,Yasunobu Nagata,Ryo Yamamoto,Yusuke Sato,Aiko Sato-Otsubo,Ayana Kon,Masao Nagasaki,George Chalkidis,Yutaka Suzuki,Masashi Shiosaka,Ryoichiro Kawahata,Tomoyuki Yamaguchi,Makoto Otsu,Naoshi Obara,Mamiko Sakata-Yanagimoto,Ken Ishiyama,Hiraku Mori,Florian Nolte,Wolf-Karsten Hofmann,Shuichi Miyawaki,Sumio Sugano,Claudia Haferlach,H. Phillip Koeffler,H. Phillip Koeffler,Lee Yung Shih,Torsten Haferlach,Shigeru Chiba,Hiromitsu Nakauchi,Satoru Miyano,Seishi Ogawa +32 more
TL;DR: The results provide the first evidence indicating that genetic alterations of the major splicing components could be involved in human pathogenesis, also implicating a novel therapeutic possibility for myelodysplasia.
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Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
Satoshi Yamazaki,Hideo Ema,Göran Karlsson,Tomoyuki Yamaguchi,Hiroyuki Miyoshi,Seiji Shioda,Makoto Mark Taketo,Stefan Karlsson,Atsushi Iwama,Hiromitsu Nakauchi +9 more
TL;DR: It is proposed that glial cells are components of a BM niche and maintain HSC hibernation by regulating activation of latent TGF-β, which is produced as a latent form by a variety of cells.
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Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.
Toshihiro Kobayashi,Tomoyuki Yamaguchi,Sanae Hamanaka,Megumi Kato-Itoh,Yuji Yamazaki,Makoto Ibata,Hideyuki Sato,Youn-Su Lee,Joichi Usui,A. S. Knisely,Masumi Hirabayashi,Masumi Hirabayashi,Hiromitsu Nakauchi +12 more
TL;DR: Proof of principle for interspecific blastocyst complementation and for generation in vivo of organs derived from donor PSCs using a xenogenic environment is provided.
Journal ArticleDOI
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
Ayana Kon,Lee Yung Shih,Masashi Minamino,Masashi Sanada,Masashi Sanada,Yuichi Shiraishi,Yasunobu Nagata,Kenichi Yoshida,Yusuke Okuno,Masashige Bando,Ryuichiro Nakato,Shumpei Ishikawa,Shumpei Ishikawa,Aiko Sato-Otsubo,Genta Nagae,Aiko Nishimoto,Claudia Haferlach,Daniel Nowak,Yusuke Sato,Tamara Alpermann,Masao Nagasaki,Teppei Shimamura,Hiroko Tanaka,Kenichi Chiba,Ryo Yamamoto,Tomoyuki Yamaguchi,Makoto Otsu,Naoshi Obara,Mamiko Sakata-Yanagimoto,Tsuyoshi Nakamaki,Ken Ishiyama,Florian Nolte,Wolf-Karsten Hofmann,Shuichi Miyawaki,Shigeru Chiba,Hiraku Mori,Hiromitsu Nakauchi,H. Phillip Koeffler,H. Phillip Koeffler,Hiroyuki Aburatani,Torsten Haferlach,Katsuhiko Shirahige,Satoru Miyano,Seishi Ogawa,Seishi Ogawa +44 more
TL;DR: A role for compromised cohesin functions in myeloid leukemogenesis is suggested by the growth of leukemic cell lines harboring a mutation in RAD21 or having severely reduced expression of RAD21 and STAG2 being suppressed by forced expression of wild-type RAD21 (Kasumi-1 cells and MOLM-13 cells).
Journal ArticleDOI
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
Naoya Takayama,Satoshi Nishimura,Satoshi Nishimura,Sou Nakamura,Takafumi Shimizu,Ryoko Ohnishi,Hiroshi Endo,Tomoyuki Yamaguchi,Makoto Otsu,Ken Nishimura,Ken Nishimura,Mahito Nakanishi,Akira Sawaguchi,Ryozo Nagai,Kazutoshi Takahashi,Shinya Yamanaka,Hiromitsu Nakauchi,Koji Eto +17 more
TL;DR: A specific kinetic pattern of c-MYC expression is essential for optimal generation of functional platelets from human induced pluripotent stem cells.