T
Tatiana Popova
Researcher at Curie Institute
Publications - 56
Citations - 3499
Tatiana Popova is an academic researcher from Curie Institute. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 22, co-authored 49 publications receiving 2633 citations. Previous affiliations of Tatiana Popova include French Institute of Health and Medical Research & ParisTech.
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Journal ArticleDOI
Control-FREEC
Valentina Boeva,Tatiana Popova,Kevin Bleakley,Pierre Chiche,Julie Cappo,Gudrun Schleiermacher,Isabelle Janoueix-Lerosey,Olivier Delattre,Emmanuel Barillot +8 more
TL;DR: The tool Control-FREEC is presented, that enables automatic calculation of copy number and allelic content profiles from NGS data, and consequently predicts regions of genomic alteration such as gains, losses and LOH.
Journal ArticleDOI
Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation
Tatiana Popova,Elodie Manié,Guillaume Rieunier,Virginie Caux-Moncoutier,Carole Tirapo,Thierry Dubois,Olivier Delattre,Brigitte Sigal-Zafrani,Marc A. Bollet,Michel Longy,Claude Houdayer,Xavier Sastre-Garau,Anne Vincent-Salomon,Dominique Stoppa-Lyonnet,Marc-Henri Stern +14 more
TL;DR: The genomic signature defined predicted BRCA1/2 inactivation in BLCs with 100% sensitivity and 90% specificity (97% accuracy) may ease the challenge of selecting patients for genetic testing or recruitment to clinical trials of novel emerging therapies that target DNA repair deficiencies in cancer.
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Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage
Samar Alsafadi,Alexandre Houy,Aude Battistella,Tatiana Popova,Michel Wassef,Emilie Henry,Franck Tirode,Angelos Constantinou,Sophie Piperno-Neumann,Sergio Roman-Roman,Martin Dutertre,Marc-Henri Stern +11 more
TL;DR: A better understanding of the mechanisms underlying splicing alterations induced by mutant SF3B1 in cancer is provided, and a role for alternative branchpoints in disease is revealed.
Journal ArticleDOI
Germline BAP1 mutations predispose to renal cell carcinomas.
Tatiana Popova,Lucie Hebert,Virginie Jacquemin,Sophie Gad,Virginie Caux-Moncoutier,Catherine Dubois-d’Enghien,Bénédicte Richaudeau,Xavier Renaudin,Jason Sellers,André Nicolas,Xavier Sastre-Garau,Laurence Desjardins,Gabor Gyapay,Virginie Raynal,Olga M. Sinilnikova,Nadine Andrieu,Elodie Manié,Antoine De Pauw,Paul Gesta,Valérie Bonadona,Christine Maugard,Clotilde Penet,Marie-Françoise Avril,Emmanuel Barillot,Emmanuel Barillot,Odile Cabaret,Olivier Delattre,Stéphane Richard,Olivier Caron,M. Benfodda,Hui-Han Hu,Nadem Soufir,Brigitte Bressac-de Paillerets,Dominique Stoppa-Lyonnet,Dominique Stoppa-Lyonnet,Marc-Henri Stern +35 more
TL;DR: Using whole-exome sequencing and tumor profiling in a family prone to cases of RCC, a germline BAP1 mutation c.277A>G (p.Thr93Ala) is identified as the probable genetic basis of R CC predisposition and BAP 1 was found to be inactivated in RCC-affected individuals from this family.
Journal ArticleDOI
Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays
Tatiana Popova,Elodie Manié,Dominique Stoppa-Lyonnet,Guillem Rigaill,Guillem Rigaill,Emmanuel Barillot,Emmanuel Barillot,Marc-Henri Stern +7 more
TL;DR: This work describes a method for automatic detection of absolute segmental copy numbers and genotype status in complex cancer genome profiles measured with single-nucleotide polymorphism (SNP) arrays based on pattern recognition of segmented and smoothed copy number and allelic imbalance profiles.