T
Tatyana D. Fedorova
Researcher at Aarhus University Hospital
Publications - 37
Citations - 1420
Tatyana D. Fedorova is an academic researcher from Aarhus University Hospital. The author has contributed to research in topics: Parkinson's disease & Medicine. The author has an hindex of 12, co-authored 29 publications receiving 820 citations. Previous affiliations of Tatyana D. Fedorova include Aarhus University.
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Journal ArticleDOI
Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study
Jacob Horsager,Katrine B. Andersen,Karoline Knudsen,Casper Skjærbæk,Tatyana D. Fedorova,Niels Okkels,Eva Schaeffer,Sarah K Bonkat,Jacob Geday,Marit Otto,Michael Sommerauer,Erik H. Danielsen,Einar Bech,Jonas Kraft,Ole Lajord Munk,Sandra D Hansen,Nicola Pavese,Nicola Pavese,Robert Göder,David J. Brooks,David J. Brooks,Daniela Berg,Per Borghammer +22 more
TL;DR: The existence of brain-first and body-first subtypes of Parkinson's disease is supported by quantifying neuronal dysfunction in structures corresponding to Braak stages I, II and III involvement in three distinct patient groups using multimodal imaging.
Journal ArticleDOI
In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study
Karoline Knudsen,Tatyana D. Fedorova,Allan K Hansen,Michael Sommerauer,Marit Otto,Kristina Bacher Svendsen,Adjmal Nahimi,Morten Gersel Stokholm,Nicola Pavese,Nicola Pavese,Nicola Pavese,Christoph P. Beier,David J. Brooks,David J. Brooks,David J. Brooks,Per Borghammer +15 more
TL;DR: Patients with idiopathic REM sleep behaviour disorder had fully developed pathology in the peripheral autonomic nervous system and the locus coeruleus, equal to that in diagnosed Parkinson's disease.
Journal ArticleDOI
Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET
Trine Gjerløff,Tatyana D. Fedorova,Karoline Knudsen,Ole Lajord Munk,Adjmal Nahimi,Steen Jacobsen,Erik H. Danielsen,Astrid Juhl Terkelsen,John H. L. Hansen,Nicola Pavese,Nicola Pavese,David J. Brooks,David J. Brooks,Per Borghammer +13 more
TL;DR: Investigation of 5-[(11)C]-methoxy-donepezil positron emission tomography tracer in patients with early-to-moderate Parkinson's disease found decreases in donepezil binding may represent a marker of parasympathetic denervation of internal organs, but further validation studies are needed.
Journal ArticleDOI
Evaluation of the noradrenergic system in Parkinson's disease: an 11C-MeNER PET and neuromelanin MRI study.
Michael Sommerauer,Tatyana D. Fedorova,Allan K Hansen,Karoline Knudsen,Marit Otto,Jesper Jeppesen,Yoon Frederiksen,Jakob Udby Blicher,Jacob Geday,Adjmal Nahimi,Malene Flensborg Damholdt,David J. Brooks,David J. Brooks,David J. Brooks,Per Borghammer +14 more
TL;DR: Reduced noradrenergic function in Parkinson's disease was linked to the presence of RBD and associated with cognitive deterioration and orthostatic hypotension and may be of relevance when treating these conditions in Parkinson’s disease.
Journal ArticleDOI
In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET
Allan K Hansen,Karoline Knudsen,Thea P. Lillethorup,Anne M. Landau,Peter Parbo,Tatyana D. Fedorova,Hélène Audrain,Dirk Bender,Karen Østergaard,David J. Brooks,Per Borghammer +10 more
TL;DR: A more severe loss of striatal nerve terminal function compared with neuronal cell bodies is suggested in Parkinson's disease, in accordance with the post-mortem literature.