K
Karoline Knudsen
Researcher at Aarhus University Hospital
Publications - 56
Citations - 2141
Karoline Knudsen is an academic researcher from Aarhus University Hospital. The author has contributed to research in topics: Parkinson's disease & Medicine. The author has an hindex of 16, co-authored 43 publications receiving 1333 citations. Previous affiliations of Karoline Knudsen include Aarhus University.
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Journal ArticleDOI
Gastrointestinal Dysfunction in Parkinson’s Disease
TL;DR: Bowel management for these people must remain empirical until well-designed controlled trials with adequate numbers and clinically relevant outcome measures become available, according to the conclusion from the latest Cochrane review on treatment of bowel dysfunction in central neurological diseases.
Journal ArticleDOI
Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study
Jacob Horsager,Katrine B. Andersen,Karoline Knudsen,Casper Skjærbæk,Tatyana D. Fedorova,Niels Okkels,Eva Schaeffer,Sarah K Bonkat,Jacob Geday,Marit Otto,Michael Sommerauer,Erik H. Danielsen,Einar Bech,Jonas Kraft,Ole Lajord Munk,Sandra D Hansen,Nicola Pavese,Nicola Pavese,Robert Göder,David J. Brooks,David J. Brooks,Daniela Berg,Per Borghammer +22 more
TL;DR: The existence of brain-first and body-first subtypes of Parkinson's disease is supported by quantifying neuronal dysfunction in structures corresponding to Braak stages I, II and III involvement in three distinct patient groups using multimodal imaging.
Journal ArticleDOI
In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study
Karoline Knudsen,Tatyana D. Fedorova,Allan K Hansen,Michael Sommerauer,Marit Otto,Kristina Bacher Svendsen,Adjmal Nahimi,Morten Gersel Stokholm,Nicola Pavese,Nicola Pavese,Nicola Pavese,Christoph P. Beier,David J. Brooks,David J. Brooks,David J. Brooks,Per Borghammer +15 more
TL;DR: Patients with idiopathic REM sleep behaviour disorder had fully developed pathology in the peripheral autonomic nervous system and the locus coeruleus, equal to that in diagnosed Parkinson's disease.
Journal ArticleDOI
Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET
Trine Gjerløff,Tatyana D. Fedorova,Karoline Knudsen,Ole Lajord Munk,Adjmal Nahimi,Steen Jacobsen,Erik H. Danielsen,Astrid Juhl Terkelsen,John H. L. Hansen,Nicola Pavese,Nicola Pavese,David J. Brooks,David J. Brooks,Per Borghammer +13 more
TL;DR: Investigation of 5-[(11)C]-methoxy-donepezil positron emission tomography tracer in patients with early-to-moderate Parkinson's disease found decreases in donepezil binding may represent a marker of parasympathetic denervation of internal organs, but further validation studies are needed.
Journal ArticleDOI
Evaluation of the noradrenergic system in Parkinson's disease: an 11C-MeNER PET and neuromelanin MRI study.
Michael Sommerauer,Tatyana D. Fedorova,Allan K Hansen,Karoline Knudsen,Marit Otto,Jesper Jeppesen,Yoon Frederiksen,Jakob Udby Blicher,Jacob Geday,Adjmal Nahimi,Malene Flensborg Damholdt,David J. Brooks,David J. Brooks,David J. Brooks,Per Borghammer +14 more
TL;DR: Reduced noradrenergic function in Parkinson's disease was linked to the presence of RBD and associated with cognitive deterioration and orthostatic hypotension and may be of relevance when treating these conditions in Parkinson’s disease.