T
Taylor B. Bertucci
Researcher at Rensselaer Polytechnic Institute
Publications - 7
Citations - 109
Taylor B. Bertucci is an academic researcher from Rensselaer Polytechnic Institute. The author has contributed to research in topics: Neurodegeneration & Biology. The author has an hindex of 2, co-authored 5 publications receiving 22 citations. Previous affiliations of Taylor B. Bertucci include Northeastern University.
Papers
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Journal ArticleDOI
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Kathryn R. Bowles,M. Catarina Silva,Kristen Whitney,Taylor B. Bertucci,Joshua E. Berlind,Jesse D. Lai,Jesse D. Lai,Jacob C. Garza,Nathan C. Boles,Sidhartha Mahali,Kevin H. Strang,Jacob A. Marsh,Cynthia Chen,Derian A. Pugh,Yiyuan Liu,Ronald E. Gordon,Susan K. Goderie,Rebecca Chowdhury,Steven Lotz,Keith P. Lane,John F. Crary,Stephen J. Haggarty,Celeste M. Karch,Justin K. Ichida,Alison Goate,Sally Temple +25 more
TL;DR: In this article, the authors used human induced pluripotent stem cell (iPSC)-derived cerebral organoids expressing tau-V337M and isogenic corrected controls to discover early alterations because of the mutation that precede neurodegeneration.
Journal ArticleDOI
Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate
Taylor B. Bertucci,Guohao Dai +1 more
TL;DR: It is explored how altering immobilized biochemical cues and biophysical cues such as dimensionality, stiffness, and topography can enhance the authors' control over stem cell fates.
Journal ArticleDOI
Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol
Stella M. K. Glasauer,Susan K. Goderie,Jennifer N. Rauch,Elmer Guzman,Morgane Audouard,Taylor B. Bertucci,Shona Joy,Emma Rommelfanger,Gabriel Luna,Erica Keane-Rivera,Steven Lotz,Susan M. Borden,Aaron M. Armando,Oswald Quehenberger,Sally Temple,Kenneth S. Kosik +15 more
TL;DR: The authors found that the cholesterol biosynthesis pathway in astrocytes was the top upregulated gene set compared with isogenic controls by single-cell RNA sequencing (scRNA-seq).
Journal ArticleDOI
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
Yong Huang,Rut Tejero,Vivian K. Lee,Concetta Brusco,Theodore C Hannah,Taylor B. Bertucci,Chrystian Junqueira Alves,Igor Katsyv,Michael Kluge,Ramsey A. Foty,Bin Zhang,Caroline C. Friedel,Guohao Dai,Hongyan Zou,Roland H. Friedel +14 more
TL;DR: In this article, the authors show that GBM cells upregulate guidance receptor Plexin-B2 to gain invasiveness by adjusting cell adhesiveness, migratory responses to different matrix stiffness, and actomyosin dynamics.
Book ChapterDOI
Differentiating Human Pluripotent Stem Cells to Vascular Endothelial Cells for Regenerative Medicine, Tissue Engineering, and Disease Modeling.
TL;DR: In this article, mesoderm progenitor cells are derived via WNT pathway activation and maturation is achieved with exogenous vascular endothelial growth factor A (VEGFA) and basic fibroblast growth factor 2 (bFGF2).