T
Teck Yew Low
Researcher at National University of Malaysia
Publications - 87
Citations - 6679
Teck Yew Low is an academic researcher from National University of Malaysia. The author has contributed to research in topics: Medicine & Proteomics. The author has an hindex of 24, co-authored 71 publications receiving 5411 citations. Previous affiliations of Teck Yew Low include Utrecht University & National University of Singapore.
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Journal ArticleDOI
The CRAPome: a contaminant repository for affinity purification–mass spectrometry data
Dattatreya Mellacheruvu,Zachary Wright,Amber L. Couzens,Jean-Philippe Lambert,Nicole St-Denis,Tuo Li,Yana Miteva,Simon Hauri,Mihaela E. Sardiu,Teck Yew Low,Vincentius A. Halim,Vincentius A. Halim,Richard D. Bagshaw,Nina C. Hubner,Abdallah Al-Hakim,Annie Bouchard,Denis Faubert,Damian Fermin,Wade H. Dunham,Marilyn Goudreault,Zhen Yuan Lin,Beatriz Gonzalez Badillo,Tony Pawson,Daniel Durocher,Benoit Coulombe,Ruedi Aebersold,Ruedi Aebersold,Giulio Superti-Furga,Jacques Colinge,Albert J. R. Heck,Hyungwon Choi,Matthias Gstaiger,Shabaz Mohammed,Ileana M. Cristea,Keiryn L. Bennett,Michael P. Washburn,Michael P. Washburn,Brian Raught,Rob M. Ewing,Rob M. Ewing,Anne-Claude Gingras,Alexey I. Nesvizhskii +41 more
TL;DR: The contaminant repository for affinity purification (the CRAPome) is presented and its use for scoring protein-protein interactions is described and aggregating negative controls from multiple AP-MS studies can increase coverage and improve the characterization of background associated with a given experimental protocol.
Journal ArticleDOI
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
Wim de Lau,Nick Barker,Nick Barker,Teck Yew Low,Bon-Kyoung Koo,Vivian S. W. Li,Hans Teunissen,Pekka Kujala,Andrea Haegebarth,Andrea Haegebarth,Peter J. Peters,Marc van de Wetering,Daniel E. Stange,J. van Es,Daniele Guardavaccaro,Richard B.M. Schasfoort,Yasuaki Mohri,Katsuhiko Nishimori,Shabaz Mohammed,Albert J. R. Heck,Hans Clevers +20 more
TL;DR: Genetic deletion of Lgr4/5 in mouse intestinal crypt cultures phenocopies withdrawal of Rspo1 and can be rescued by Wnt pathway activation, which will guide future studies towards the application of R-spondins for regenerative purposes of tissues expressing Lgr5 homologues.
Journal ArticleDOI
Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
Vivian S. W. Li,Ser Sue Ng,Paul J. Boersema,Teck Yew Low,Wouter R. Karthaus,Jan P. Gerlach,Shabaz Mohammed,Albert J. R. Heck,Madelon M. Maurice,Tokameh Mahmoudi,Tokameh Mahmoudi,Hans Clevers +11 more
TL;DR: The results demonstrate that β-catenin is not only phosphorylated inside the Axin1 complex, but also ubiquinated and degraded via the proteasome, all within an intact Axin 1 complex.
Journal ArticleDOI
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
Bon-Kyoung Koo,Maureen Spit,Ingrid Jordens,Teck Yew Low,Daniel E. Stange,Marc van de Wetering,Johan H. van Es,Shabaz Mohammed,Albert J. R. Heck,Madelon M. Maurice,Hans Clevers +10 more
TL;DR: It is concluded that RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation.
Journal ArticleDOI
Six alternative proteases for mass spectrometry-based proteomics beyond trypsin
TL;DR: This protocol is formulated to promote ease of use and robustness, which enable parallel digestion with each of the six tested proteases, namely chymotrypsin, LysC, LysN, AspN, GluC and ArgC.