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Ileana M. Cristea
Researcher at Princeton University
Publications - 202
Citations - 12261
Ileana M. Cristea is an academic researcher from Princeton University. The author has contributed to research in topics: Biology & Proteomics. The author has an hindex of 54, co-authored 182 publications receiving 10059 citations. Previous affiliations of Ileana M. Cristea include University of Bergen & University of Manchester.
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The CRAPome: a contaminant repository for affinity purification–mass spectrometry data
Dattatreya Mellacheruvu,Zachary Wright,Amber L. Couzens,Jean-Philippe Lambert,Nicole St-Denis,Tuo Li,Yana Miteva,Simon Hauri,Mihaela E. Sardiu,Teck Yew Low,Vincentius A. Halim,Vincentius A. Halim,Richard D. Bagshaw,Nina C. Hubner,Abdallah Al-Hakim,Annie Bouchard,Denis Faubert,Damian Fermin,Wade H. Dunham,Marilyn Goudreault,Zhen Yuan Lin,Beatriz Gonzalez Badillo,Tony Pawson,Daniel Durocher,Benoit Coulombe,Ruedi Aebersold,Ruedi Aebersold,Giulio Superti-Furga,Jacques Colinge,Albert J. R. Heck,Hyungwon Choi,Matthias Gstaiger,Shabaz Mohammed,Ileana M. Cristea,Keiryn L. Bennett,Michael P. Washburn,Michael P. Washburn,Brian Raught,Rob M. Ewing,Rob M. Ewing,Anne-Claude Gingras,Alexey I. Nesvizhskii +41 more
TL;DR: The contaminant repository for affinity purification (the CRAPome) is presented and its use for scoring protein-protein interactions is described and aggregating negative controls from multiple AP-MS studies can increase coverage and improve the characterization of background associated with a given experimental protocol.
Journal ArticleDOI
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Aaron D Goldberg,Laura A. Banaszynski,Kyung-Min Noh,Peter W. Lewis,Simon J. Elsaesser,Sonja C. Stadler,Scott Dewell,Martin J. Law,Xingyi Guo,Xuan Li,Duancheng Wen,Duancheng Wen,Ariane Chapgier,Russell Dekelver,Jeffrey C. Miller,Ya Li Lee,Elizabeth A. Boydston,Michael C. Holmes,Philip D. Gregory,John M. Greally,Shahin Rafii,Shahin Rafii,Chingwen Yang,Peter J. Scambler,David Garrick,Richard J. Gibbons,Douglas R. Higgs,Ileana M. Cristea,Fyodor D. Urnov,Deyou Zheng,C. David Allis +30 more
TL;DR: It is demonstrated that multiple and distinct factors are responsible for H3.3 localization at specific genomic locations in mammalian cells.
Journal ArticleDOI
Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity
Rommel A. Mathias,Todd M. Greco,Adam Oberstein,Hanna G. Budayeva,Rumela Chakrabarti,Elizabeth A. Rowland,Yibin Kang,Thomas Shenk,Ileana M. Cristea +8 more
TL;DR: SIRT4 is established as a cellular lipoamidase that regulates the pyruvate dehydrogenase complex (PDH) and enzymatically hydrolyzes the lipoamide cofactors from the E2 component dihydrolipoyllysine acetyltransferase (DLAT), diminishing PDH activity.
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Induction of autophagy in axonal dystrophy and degeneration.
Qing Jun Wang,Yaomei Ding,D. Stave Kohtz,Noboru Mizushima,Ileana M. Cristea,Michael P. Rout,Brian T. Chait,Yun Zhong,Nathaniel Heintz,Zhenyu Yue +9 more
TL;DR: It is proposed that induction of autophagy serves as an early stress response in axonal dystrophy and may participate in the remodeling of axon structures under normal and pathogenic conditions.
Journal ArticleDOI
Enzyme clustering accelerates processing of intermediates through metabolic channeling
Michele Castellana,Maxwell Z. Wilson,Yi-Fan Xu,Preeti Joshi,Ileana M. Cristea,Joshua D. Rabinowitz,Zemer Gitai,Ned S. Wingreen +7 more
TL;DR: A quantitative model is presented to demonstrate that coclustering multiple enzymes into compact agglomerates accelerates the processing of intermediates, yielding the same efficiency benefits as direct channeling, a well-known mechanism in which enzymes are funneled between enzyme active sites through a physical tunnel.