D
Daniella M. Mizurini
Researcher at Federal University of Rio de Janeiro
Publications - 24
Citations - 802
Daniella M. Mizurini is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Neutrophil extracellular traps & Thrombin. The author has an hindex of 14, co-authored 23 publications receiving 596 citations.
Papers
More filters
Journal ArticleDOI
Tumor-Derived Exosomes Induce the Formation of Neutrophil Extracellular Traps: Implications For The Establishment of Cancer-Associated Thrombosis
Ana C. Leal,Daniella M. Mizurini,Tainá Gomes,Natalia C. Rochael,Elvira M. Saraiva,Marcos Vinicios Salles Dias,Claudio C. Werneck,Micheli S. Sielski,Cristina P. Vicente,Robson Q. Monteiro +9 more
TL;DR: Observations suggest that tumor-derived exosomes and neutrophils may act cooperatively in the establishment of cancer-associated thrombosis.
Journal ArticleDOI
Evoking picomolar binding in RNA by a single phosphorodithioate linkage.
N. Dinuka Abeydeera,Martin Egli,Nehemiah Cox,Karen Mercier,Jonas N. Conde,Pradeep S. Pallan,Daniella M. Mizurini,Malgorzata Sierant,Fatima-Ezzahra Hibti,Tom Hassell,Tianzhi Wang,Feng Wu Liu,Hong Min Liu,Carlos Martinez,Anil K. Sood,Terry P. Lybrand,Chiraz Frydman,Robson Q. Monteiro,Richard H. Gomer,Barbara Nawrot,Xianbin Yang +20 more
TL;DR: The use of the phosphorodithioate (PS2) substitution on a single nucleotide of RNA aptamers is reported to dramatically improve target binding affinity by ∼1000-fold (from nanomolar to picomolar).
Journal ArticleDOI
Lufaxin, a Novel Factor Xa Inhibitor From the Salivary Gland of the Sand Fly Lutzomyia longipalpis, Blocks Protease-Activated Receptor 2 Activation and Inhibits Inflammation and Thrombosis In Vivo
Nicolas Collin,Teresa C.F. Assumpção,Daniella M. Mizurini,Dana C. Gilmore,Angélica Dutra-Oliveira,Michalis Kotsyfakis,Anderson Sá-Nunes,Clarissa Teixeira,José M. C. Ribeiro,Robson Q. Monteiro,Jesus G. Valenzuela,Ivo M.B. Francischetti +11 more
TL;DR: Salivary gland of sand flies was found to inhibit FXa and to interact with the enzyme, and Lufaxin belongs to a novel family of slow-tight FXa inhibitors, which display antithrombotic and anti-inflammatory activities.
Journal ArticleDOI
IL-1β Blockade Attenuates Thrombosis in a Neutrophil Extracellular Trap-Dependent Breast Cancer Model
Tainá Gomes,Carolina B. S. Várady,André Luiz Lourenço,Daniella M. Mizurini,Araci M. R. Rondon,Ana C. Leal,Barbara Simonson Gonçalves,Dumith Chequer Bou-Habib,Dumith Chequer Bou-Habib,Emiliano Medei,Robson Q. Monteiro +10 more
TL;DR: The results demonstrate that IL-1β might be a feasible target to attenuate cancer-associated thrombosis, particularly in cancer types that rely on increased G-CSF production and involvement of NET formation.
Journal ArticleDOI
Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo
Dongying Ma,Daniella M. Mizurini,Teresa C.F. Assumpção,Yuan Li,Yanwei Qi,Michail Kotsyfakis,José M. C. Ribeiro,Robson Q. Monteiro,Ivo M.B. Francischetti +8 more
TL;DR: Results imply that FXIa is the primary in vivo target for Desmolaris at antithrombotic concentrations, under conditions in which the coagulation activation, particularly the contact pathway, plays a major pathological role.