K
Kumpei Tokuyama
Researcher at University of Tsukuba
Publications - 158
Citations - 8576
Kumpei Tokuyama is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 42, co-authored 151 publications receiving 7655 citations. Previous affiliations of Kumpei Tokuyama include Ehime University.
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Journal ArticleDOI
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Toshimasa Yamauchi,Yasunori Nio,Toshiyuki Maki,Masaki Kobayashi,Takeshi Takazawa,Masato Iwabu,Miki Okada-Iwabu,Sachiko Kawamoto,Naoto Kubota,Tetsuya Kubota,Yusuke Ito,Junji Kamon,Atsushi Tsuchida,Katsuyoshi Kumagai,Hideki Kozono,Yusuke Hada,Hitomi Ogata,Kumpei Tokuyama,Masaki Tsunoda,Tomohiro Ide,Kouji Murakami,Motoharu Awazawa,Iseki Takamoto,Philippe Froguel,Kazuo Hara,Kazuyuki Tobe,Ryozo Nagai,Kohjiro Ueki,Takashi Kadowaki +28 more
TL;DR: Adenovirus-mediated expression of AdipoR1 and R2 in the liver of Lepr−/− mice increased AMP-activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor (PPAR)-α signaling pathways, respectively, and abolished adiponectin binding and actions, leading to insulin resistance and marked glucose intolerance in vivo.
Journal ArticleDOI
Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance
Nozomu Kamei,Kazuyuki Tobe,Ryo Suzuki,Mitsuru Ohsugi,Taku Watanabe,Naoto Kubota,Norie Ohtsuka-Kowatari,Katsuyoshi Kumagai,Kentaro Q. Sakamoto,Masatoshi Kobayashi,Toshimasa Yamauchi,Kohjiro Ueki,Yumiko Oishi,Satoshi Nishimura,Ichiro Manabe,Haruo Hashimoto,Yasuyuki Ohnishi,Hitomi Ogata,Kumpei Tokuyama,Masaki Tsunoda,Tomohiro Ide,Koji Murakami,Ryozo Nagai,Takashi Kadowaki +23 more
TL;DR: It is concluded that both paracrine and endocrine effects of MCP-1 may contribute to the development of insulin resistance in aP2-M CP-1 mice.
Journal ArticleDOI
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
Masato Iwabu,Toshimasa Yamauchi,Miki Okada-Iwabu,Koji Sato,Tatsuro Nakagawa,Masaaki Funata,Mamiko Yamaguchi,Shigeyuki Namiki,Ryo Nakayama,Mitsuhisa Tabata,Hitomi Ogata,Naoto Kubota,Iseki Takamoto,Yukiko K. Hayashi,Naoko Yamauchi,Hironori Waki,Masashi Fukayama,Ichizo Nishino,Kumpei Tokuyama,Kohjiro Ueki,Yuichi Oike,Satoshi Ishii,Kenzo Hirose,Takao Shimizu,Kazushige Touhara,Takashi Kadowaki +25 more
TL;DR: Evidence is provided that adiponectin induces extracellular Ca2+ influx by AdipoR1, which was necessary for subsequent activation of Ca2-/calmodulin-dependent protein kinase kinase β (CaMKKβ), AMPK and SIRT1, increased expression and decreased acetylation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1 α), and increased mitochondria in myocytes.
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A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
Miki Okada-Iwabu,Toshimasa Yamauchi,Masato Iwabu,Teruki Honma,Ken-ichi Hamagami,Koichi Matsuda,Mamiko Yamaguchi,Hiroaki Tanabe,Tomomi Kimura-Someya,Mikako Shirouzu,Hitomi Ogata,Kumpei Tokuyama,Kohjiro Ueki,Tetsuo Nagano,Akiko Tanaka,Shigeyuki Yokoyama,Takashi Kadowaki +16 more
TL;DR: AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed a high-fat diet, and is a promising therapeutic approach for the treatment of obesity-related diseases such as type 2 diabetes.
Journal ArticleDOI
Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle
Tetsuya Kubota,Naoto Kubota,Hiroki Kumagai,Shinichi Yamaguchi,Hideki Kozono,Takehiro Takahashi,Mariko Inoue,Shinsuke Itoh,Iseki Takamoto,Takayoshi Sasako,Katsuyoshi Kumagai,Tomoko Kawai,Shinji Hashimoto,Tsuneo Kobayashi,Maki Sato,Kumpei Tokuyama,Satoshi Nishimura,Masaki Tsunoda,Tomohiro Ide,Koji Murakami,Tomomi Yamazaki,Osamu Ezaki,Koichi Kawamura,Hirotake Masuda,Masao Moroi,Kaoru Sugi,Yuichi Oike,Hiroaki Shimokawa,Nobuyuki Yanagihara,Masato Tsutsui,Yasuo Terauchi,Kazuyuki Tobe,Ryozo Nagai,Katsuo Kamata,Kenji Inoue,Tatsuhiko Kodama,Kohjiro Ueki,Takashi Kadowaki +37 more
TL;DR: The results show that insulin signaling in endothelial cells plays a pivotal role in the regulation of glucose uptake by skeletal muscle, and improving endothelial insulin signaling may serve as a therapeutic strategy for ameliorating skeletal muscle insulin resistance.