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Yuichi Shichino
Researcher at National Institute for Basic Biology, Japan
Publications - 34
Citations - 827
Yuichi Shichino is an academic researcher from National Institute for Basic Biology, Japan. The author has contributed to research in topics: Ribosome profiling & Biology. The author has an hindex of 10, co-authored 21 publications receiving 524 citations. Previous affiliations of Yuichi Shichino include University of Tokyo.
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Journal ArticleDOI
The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA.
Shintaro Iwasaki,Shintaro Iwasaki,Wakana Iwasaki,Mari Takahashi,Ayako Sakamoto,Chiduru Watanabe,Yuichi Shichino,Stephen N. Floor,Koichi Fujiwara,Mari Mito,Kosuke Dodo,Mikiko Sodeoka,Hiroaki Imataka,Teruki Honma,Kaori Fukuzawa,Takuhiro Ito,Nicholas T. Ingolia +16 more
TL;DR: An RNA-sequence-selective interfacial inhibitor fitting into the space shaped cooperatively by protein and RNA with specific sequences is provided, providing an example of an RNA- sequence-selectives interfacial inhibition.
Journal ArticleDOI
Hexanucleotide motifs mediate recruitment of the RNA elimination machinery to silent meiotic genes
Akira Yamashita,Yuichi Shichino,Hirotsugu Tanaka,Edwige Hiriart,Leila Touat-Todeschini,Aurélia Vavasseur,Da-Qiao Ding,Yasushi Hiraoka,Yasushi Hiraoka,André Verdel,Masayuki Yamamoto +10 more
TL;DR: It is shown that Mmi1 interacts with repeats of the hexanucleotide U(U/C)AAAC that are enriched in the DSR, the determinant of selective removal (DSR), which is recognized by a YTH-family RNA-binding protein, Mmi 1.
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Genome-wide Survey of Ribosome Collision.
Peixun Han,Yuichi Shichino,Tilman Schneider-Poetsch,Mari Mito,Satoshi Hashimoto,Tsuyoshi Udagawa,Kenji Kohno,Minoru Yoshida,Yuichiro Mishima,Toshifumi Inada,Shintaro Iwasaki +10 more
TL;DR: The results provide insight into the causes and consequences of ribosome pause by dissecting collided ribosomes, and XBP1u, a precursor of endoplasmic reticulum (ER)-stress-responsive transcription factor, shows striking queues of collided Ribosomes and thus acts as a degradation substrate by Ribosome-associated quality control.
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Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast
Edwige Hiriart,Aurélia Vavasseur,Leila Touat-Todeschini,Akira Yamashita,Benoit Gilquin,Emeline Lambert,Jonathan Perot,Yuichi Shichino,Nicolas Nazaret,Cyril Boyault,Joël Lachuer,Daniel Perazza,Masayuki Yamamoto,André Verdel +13 more
TL;DR: It is shown that RITS localizes to specific meiotic genes and mRNAs and is suggested that RNAi participates in the control of sexual differentiation in fission yeast.
Journal ArticleDOI
Codon bias confers stability to human mRNAs
Fabian Hia,Sheng Fan Yang,Yuichi Shichino,Masanori Yoshinaga,Yasuhiro Murakawa,Alexis Vandenbon,Akira Fukao,Toshinobu Fujiwara,Markus Landthaler,Markus Landthaler,Tohru Natsume,Shungo Adachi,Shintaro Iwasaki,Osamu Takeuchi +13 more
TL;DR: ILF2 and ILF3 are identified as RNA‐binding proteins that differentially regulate global mRNA abundances based on codon bias and it is demonstrated thatCodon bias is a two‐pronged system that governs mRNA abundance.