T
Theresa Guo
Researcher at University of Texas MD Anderson Cancer Center
Publications - 57
Citations - 2181
Theresa Guo is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Cancer. The author has an hindex of 22, co-authored 55 publications receiving 1568 citations. Previous affiliations of Theresa Guo include National Institutes of Health & University of California, San Diego.
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Journal ArticleDOI
Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas.
Yuxuan Wang,Simeon Springer,Carolyn L. Mulvey,Natalie Silliman,Joy Schaefer,Mark Sausen,Nathan T. James,Eleni M. Rettig,Theresa Guo,Curtis R. Pickering,Justin A. Bishop,Christine H. Chung,Joseph A. Califano,Joseph A. Califano,David W. Eisele,Carole Fakhry,Carole Fakhry,Christine G. Gourin,Patrick K. Ha,Patrick K. Ha,Hyunseok Kang,Ana P. Kiess,Wayne M. Koch,Jeffrey N. Myers,Harry Quon,Jeremy D. Richmon,David Sidransky,Ralph P. Tufano,William H. Westra,Chetan Bettegowda,Luis A. Diaz,Nickolas Papadopoulos,Kenneth W. Kinzler,Bert Vogelstein,Nishant Agrawal +34 more
TL;DR: Analysis of DNA from saliva and plasma of 93 HNSCC patients found preliminary evidence suggesting that tumor DNA may be detectable in saliva before clinical evidence of tumor recurrence, which may be useful for patient monitoring if this result is confirmed in larger studies.
Journal ArticleDOI
Human papillomavirus-related carcinomas of the sinonasal tract.
Justin A. Bishop,Theresa Guo,David F. Smith,Hao Wang,Takenori Ogawa,Sara I. Pai,William H. Westra +6 more
TL;DR: The presence of high-risk HPV in 21% of sinonasal carcinomas confirms HPV as an important oncologic agent of carcinomas arising in the sin onasal tract.
Journal ArticleDOI
A Polymorphism in IRF4 Affects Human Pigmentation through a Tyrosinase-Dependent MITF/TFAP2A Pathway
Christian Praetorius,Christine Grill,Simon N. Stacey,Alexander M. Metcalf,David U. Gorkin,Kathleen C. Robinson,Eric Van Otterloo,Reuben S.Q. Kim,Kristin Bergsteinsdottir,Margret H. Ogmundsdottir,Erna Magnúsdóttir,Pravin J. Mishra,Sean Davis,Theresa Guo,M. Raza Zaidi,Agnar Helgason,Martin I. Sigurdsson,Paul S. Meltzer,Glenn Merlino,Valérie Petit,Lionel Larue,Stacie K. Loftus,David R. Adams,Ulduz Sobhiafshar,N. C. Tolga Emre,William J. Pavan,Robert A. Cornell,Aaron G. Smith,Andrew S. McCallion,David E. Fisher,Kari Stefansson,Richard A. Sturm,Eiríkur Steingrímsson +32 more
TL;DR: A SNP within an intron of the gene encoding Interferon Regulatory Factor 4, a transcription factor with no known role in melanocyte biology, is demonstrated to lie within an enhancer of IRF4 transcription in melanocytes, providing a clear example of a noncoding polymorphism that affects a phenotype by modulating a developmental gene regulatory network.
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Surgical salvage improves overall survival for patients with HPV-positive and HPV-negative recurrent locoregional and distant metastatic oropharyngeal cancer.
Theresa Guo,Jesse R Qualliotine,Patrick K. Ha,Patrick K. Ha,Joseph A. Califano,Joseph A. Califano,Young Kim,John R. Saunders,Ray G. Blanco,Gypsyamber D'Souza,Zhe Zhang,Christine H. Chung,Ana P. Kiess,Christine G. Gourin,Wayne M. Koch,Jeremy D. Richmon,Jeremy D. Richmon,Nishant Agrawal,David W. Eisele,Carole Fakhry,Carole Fakhry +20 more
TL;DR: Human papillomavirus (HPV) tumor status and surgical salvage are associated with improved prognosis for patients with recurrent oropharyngeal squamous cell carcinoma (OPSCC).
Journal ArticleDOI
Antagonistic Cross-Regulation between Sox9 and Sox10 Controls an Anti-tumorigenic Program in Melanoma
Olga Shakhova,Phil F. Cheng,Pravin J. Mishra,Daniel Zingg,Simon M. Schaefer,Julien Debbache,Jessica Häusel,Claudia Matter,Theresa Guo,Sean Davis,Paul S. Meltzer,Daniela Mihic-Probst,Holger Moch,Michael Wegner,Glenn Merlino,Mitchell P. Levesque,Reinhard Dummer,Raffaella Santoro,Paolo Cinelli,Lukas Sommer +19 more
TL;DR: It is shown that reducing SOX10 expression levels in human melanoma cells and in a genetic melanoma mouse model, efficiently abolishes tumorigenesis by inducing cell cycle exit and apoptosis and that SOX9 is required in vitro and in vivo for the anti-tumorigenic effect achieved.