Martin I. Sigurdsson

TL;DR: Recon 2, a community-driven, consensus 'metabolic reconstruction', is described, which is the most comprehensive representation of human metabolism that is applicable to computational modeling and has improved topological and functional features.

TL;DR: The authors' results indicate that antiviral antibodies against SARS-CoV-2 did not decline within 4 months after diagnosis, and antiviral antibody titers assayed by two pan-Ig assays remained on a plateau for the remainder of the study.

TL;DR: The data indicate that methylation changes over time and suggest thatmethylation maintenance may be under genetic control, and suggest the family-based Utah sample also showed intra-individual changesover time, and further demonstrated familial clustering of methylation change.

TL;DR: A SNP within an intron of the gene encoding Interferon Regulatory Factor 4, a transcription factor with no known role in melanocyte biology, is demonstrated to lie within an enhancer of IRF4 transcription in melanocytes, providing a clear example of a noncoding polymorphism that affects a phenotype by modulating a developmental gene regulatory network.

TL;DR: A high-quality mouse genome-scale metabolic reconstruction, iMM1415 (Mus Musculus, 1415 genes), is created and it is demonstrated that the mouse model can be used to perform phenotype simulations, similar to models of microbe metabolism.