Therese M. Murphy

TL;DR: Fetal brain mQTLs were enriched amongst risk loci identified in a recent large-scale genome-wide association study (GWAS) of schizophrenia, a severe psychiatric disorder with a hypothesized neurodevelopmental component and can be used to refine GWAS loci through the identification of discrete sites of variable fetal brain methylation associated with schizophrenia risk variants.

TL;DR: Assessment of genome-wide DNA methylation changes specifically associated with ulcerative colitis, Crohn's disease and IBD activity provides new insights into differential epigenetic regulation of genes and molecular pathways, which may contribute to the pathogenesis and activity of IBD.

TL;DR: The results suggest that aberrant methylation profiles affecting the hippocampus are associated with major depressive disorder and show the potential of the epigenetic twin model in neuro-psychiatric disease.

TL;DR: Findings suggest that allelic variability in SLC1A2/3, 5-HTR1B and NTRK2 may be relevant to the underlying diathesis for suicidal acts, and evidence of a 3-locus gene-gene interaction, and a putative gene-environment interaction, whereby genetic variation at the N TRK2 locus may moderate the risk associated with history of childhood abuse.

TL;DR: The investigators examined the correlation between DNA methylation and HIF3A expression in adipose tissue, reporting a signifi cant inverse correlation and drawing attention to the potential functional relevance of epigenetic variation at the identifi ed locus.