T
Thomas A. Wynn
Researcher at University of California, San Diego
Publications - 300
Citations - 61781
Thomas A. Wynn is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cytokine & Schistosoma mansoni. The author has an hindex of 111, co-authored 276 publications receiving 52854 citations. Previous affiliations of Thomas A. Wynn include Los Alamos National Laboratory & Urbana University.
Papers
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Journal ArticleDOI
Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation
Luke Barron,Amber M. Smith,Karim C. El Kasmi,Joseph E. Qualls,Xiaozhu Huang,Allen W. Cheever,Lee A. Borthwick,Mark S. Wilson,Peter J. Murray,Thomas A. Wynn +9 more
TL;DR: The results argue that Arg1 is a general feature of alternative activation but only selectively regulates Th2 responses, and attempts to experimentally or therapeutically inhibit arginase activity in the lung should be examined with caution.
Journal ArticleDOI
Unveiling the Stable Nature of the Solid Electrolyte Interphase between Lithium Metal and LiPON via Cryogenic Electron Microscopy
Diyi Cheng,Thomas A. Wynn,Xuefeng Wang,Shen Wang,Minghao Zhang,Ryosuke Shimizu,Shuang Bai,Han Nguyen,Chengcheng Fang,Min-cheol Kim,Weikang Li,Bingyu Lu,Suk Jun Kim,Ying Shirley Meng +13 more
TL;DR: In this article, a multilayer mosaic SEI structure with concentration gradients of nitrogen and phosphorous, materializing as crystallites within an amorphous matrix, was found to be stable and free of any organic lithium containing species or lithium fluoride components.
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Inducible nitric oxide synthase-deficient mice develop enhanced type 1 cytokine-associated cellular and humoral immune responses after vaccination with attenuated Schistosoma mansoni cercariae but display partially reduced resistance.
TL;DR: It is demonstrated that iNOS plays a paradoxical role in immunity to S. mansoni, both in the effector mechanism of resistance and in the down regulation of the type 1 cytokine response, which is ultimately required for NO production.
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IL-10 and TGF-β Control the Establishment of Persistent and Transmissible Infections Produced by Leishmania tropica in C57BL/6 Mice
TL;DR: Chronic infection with L. tropica appears to be established via multiple suppressive factors, which together maintain the host as a long-term reservoir of infection for vector sand flies.
Journal ArticleDOI
Conventional NK Cells Can Produce IL-22 and Promote Host Defense in Klebsiella pneumoniae Pneumonia
Xin Xu,Ido D. Weiss,Hongwei H. Zhang,Satya P. Singh,Thomas A. Wynn,Mark S. Wilson,Joshua M. Farber +6 more
TL;DR: The data suggest that, during pulmonary infection of mice with K. pneumoniae, conventional NK cells are required for optimal host defense, which includes the production of IL-22, which is found in both wild-type and Rag2−/− mice.