T
Thomas A. Wynn
Researcher at University of California, San Diego
Publications - 300
Citations - 61781
Thomas A. Wynn is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cytokine & Schistosoma mansoni. The author has an hindex of 111, co-authored 276 publications receiving 52854 citations. Previous affiliations of Thomas A. Wynn include Los Alamos National Laboratory & Urbana University.
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Journal ArticleDOI
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain
Thirumalai R. Ramalingam,John T. Pesce,Faruk Sheikh,Allen W. Cheever,Margaret M. Mentink-Kane,Mark S. Wilson,Sean Stevens,David M. Valenzuela,Andrew J. Murphy,George D. Yancopoulos,Joseph F. Urban,Raymond P. Donnelly,Thomas A. Wynn +12 more
TL;DR: Type I and II IL-4 receptors exert distinct effects on immune responses, and Il13ra1−/− mice showed much less mortality after infection with Schistosoma mansoni and much more susceptibility to Nippostrongylus brasiliensis.
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Schistosoma mansoni infection in eosinophil lineage–ablated mice
Jonathan M. Swartz,Kimberly D. Dyer,Allen W. Cheever,Thirumalai R. Ramalingam,Lesley Pesnicak,Joseph B. Domachowske,James J. Lee,Nancy A. Lee,Paul S. Foster,Thomas A. Wynn,Helene F. Rosenberg +10 more
TL;DR: The data indicate that eosinophil ablation has no impact on traditional measures of disease in the S mansoni infection model in mice, but eos inophils may have unexplored immunomodulatory contributions to this disease process.
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Lewis base activation of Lewis acids: catalytic, enantioselective addition of silyl ketene acetals to aldehydes.
TL;DR: The high levels of regio-, anti diastereo-, and enantioselectivity observed in these reactions can be rationalized through consideration of an open transition structure where steric interactions between the silyl cation complex and the approaching nucleophile are dominant.
Journal ArticleDOI
Lewis base activation of Lewis acids: catalytic enantioselective allylation and propargylation of aldehydes.
Scott E. Denmark,Thomas A. Wynn +1 more
Journal ArticleDOI
Th2 cytokine-Induced Alterations in Intestinal Smooth Muscle Function Depend on Alternatively Activated Macrophages
Aiping Zhao,Joseph F. Urban,Robert M. Anthony,Rex Sun,Jennifer A. Stiltz,Nico van Rooijen,Thomas A. Wynn,William C. Gause,Terez Shea-Donohue +8 more
TL;DR: Data show that the phenotype of macrophages is determined by the local immune environment and that alternatively activated macrophage markers play a major role in the effects of Th2 cytokines, IL-4 and IL-13, on intestinal smooth muscle function.