T
Thomas A. Wynn
Researcher at University of California, San Diego
Publications - 300
Citations - 61781
Thomas A. Wynn is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cytokine & Schistosoma mansoni. The author has an hindex of 111, co-authored 276 publications receiving 52854 citations. Previous affiliations of Thomas A. Wynn include Los Alamos National Laboratory & Urbana University.
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Journal ArticleDOI
Regional differences in human biliary tissues and corresponding in vitro derived organoids.
Casey A. Rimland,Samantha G. Tilson,Carola M. Morell,Carola M. Morell,Rute A. Tomaz,Rute A. Tomaz,Wei-Yu Lu,Wei-Yu Lu,Simone E. Adams,Simone E. Adams,Nikitas Georgakopoulos,Francisco Otaizo-Carrasquero,Timothy G. Myers,John R. Ferdinand,Richard L. Gieseck,Fotios Sampaziotis,Fotios Sampaziotis,Olivia C. Tysoe,Olivia C. Tysoe,Alexander Ross,Judith Kraiczy,Brandon T Wesley,Brandon T Wesley,Daniele Muraro,Daniele Muraro,Daniele Muraro,Matthias Zilbauer,Gabriel C. Oniscu,Nicholas R.F. Hannan,Nicholas R.F. Hannan,Stuart J. Forbes,Kourosh Saeb-Parsy,Thomas A. Wynn,Ludovic Vallier,Ludovic Vallier +34 more
TL;DR: The biliary tree is a series of ductular tissues responsible for the drainage of bile and pancreatic secretions and the relationship between these organs and their tissues of origin, and to each other, is largely unknown.
Journal ArticleDOI
Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization.
Helton C. Santiago,Elyse LeeVan,Sasisekhar Bennuru,Flávia L. Ribeiro-Gomes,Ellen Mueller,Mark S. Wilson,Thomas A. Wynn,David N. Garboczi,Joseph F. Urban,Edward Mitre,Thomas B. Nutman +10 more
TL;DR: Investigation of the cross-reactivity between a major glutathione-S transferase allergen of cockroach and the WbGST, a major lymphatic filarial pathogen of humans, demonstrates that helminth glutathion-Stransferase and the aeroallergen Bla g 5 share epitopes that can induce allergic cross-sensitization.
Journal ArticleDOI
Correction tp Macrophage activation and polarization: Nomenclature and experimental guidelines [Immunity, 41, 2014 (14-20)]
Peter J. Murray,Judith E. Allen,Subhra K. Biswas,Edward A. Fisher,Derek W. Gilroy,Sergij Goerdt,Siamon Gordon,John A. Hamilton,Lionel B. Ivashkiv,Toby Lawrence,Massimo Locati,Alberto Mantovani,Fernando O. Martinez,Jean Louis Mege,David M. Mosser,Gioacchino Natoli,Jeroen P. J. Saeij,Joachim L. Schultze,Kari Ann Shirey,Antonio Sica,Jill Suttles,Irina A. Udalova,Jo A. Van Ginderachter,Stefanie N. Vogel,Thomas A. Wynn +24 more
Journal ArticleDOI
Basophils trump dendritic cells as APCs for T(H)2 responses.
TL;DR: Three new papers suggest that basophils initiate allergen- and helminth-driven CD4+ T helper type 2 responses by functioning as antigen-presenting cells in draining lymph nodes.
are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
Dragana Jankovic,Marika C. Kullberg,Carl G. Feng,Romina S. Goldszmid,Carmen M. Collazo,Mark R. Wilson,Thomas A. Wynn,Masahito Kamanaka,Richard A. Flavell,Alan Sher +9 more
TL;DR: Findings indicate that IL-10 production by CD4+ T lymphocytes need not involve a distinct regulatory Th cell subset but can be generated in Th1 cells as part of the effector response to intracellular pathogens.