T
Thomas A. Wynn
Researcher at University of California, San Diego
Publications - 300
Citations - 61781
Thomas A. Wynn is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cytokine & Schistosoma mansoni. The author has an hindex of 111, co-authored 276 publications receiving 52854 citations. Previous affiliations of Thomas A. Wynn include Los Alamos National Laboratory & Urbana University.
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Journal ArticleDOI
Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.
Jennifer M. Fitzpatrick,José M. Fuentes,Iain W. Chalmers,Thomas A. Wynn,Manuel Modolell,Karl F. Hoffmann,Matthias Hesse +6 more
TL;DR: It is demonstrated for the first time that several developmental stages of the human parasite Schistosoma mansoni express arginase, which is responsible for the hydrolysis of l-arginine to l-ornithine and urea, and it is discovered that S. mansoniArginase is well adapted to the physiological conditions that exist in the human host.
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Immune deviation as a strategy for schistosomiasis vaccines designed to prevent infection and egg-induced immunopathology.
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Heat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation.
D.J.K. Yombo,D.J.K. Yombo,Margaret M. Mentink-Kane,Mark S. Wilson,Thomas A. Wynn,Satish K. Madala,Satish K. Madala +6 more
TL;DR: A pathogenic role for HSp70 is identified in hematopoietic cells during allergic airway inflammation; this illustrates the potential utility of targeting Hsp70 to alleviate allergen-induced Th2 cytokines, goblet cell hyperplasia, and airwayinflammation.
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Local Structure of Glassy Lithium Phosphorus Oxynitride Thin Films: A Combined Experimental and Ab Initio Approach
Maxwell A. T. Marple,Thomas A. Wynn,Diyi Cheng,Ryosuke Shimizu,Harris E. Mason,Y. Shirley Meng +5 more
TL;DR: In this paper, a structural model of RF-sputtered LiPON is provided, and the short-range structure results from 1D and 2D solid-state NMR experiments are compared with first principles chemical shielding calculations of Li-P-O/N crystals and ab initio molecular dynamics-generated amorphous LiPon models.
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Cytokines as determinants of disease and disease interactions.
Alan Sher,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,Dragana Jankovic,Tanya Scharton-Kersten,George S. Yap,T M Doherty,Thomas A. Wynn +7 more
TL;DR: The immune response to pathogens results in both host resistance and immunopathology, and Cytokines and in particular those lymphokines produced by Th1 and Th2 cells play a key role in determining the balance between these two immunologic outcomes.