Thomas Enzler

TL;DR: Palliative management, which may include systemic therapy, chemoradiation, and/or best supportive care, is recommended for all patients with unresectable or metastatic cancer.

TL;DR: The primary structures of human and rabbit brush border membrane beta‐glycosidase complexes (pre‐pro‐lactase‐phlorizin hydrolase, or pre‐ pro‐LPH, EC 3.2.1.23‐62) are reported, suggesting that they evolved by two cycles of partial gene duplication and have implications for the decline of LPH after weaning and for human adult‐type alactasia, and for the evolutionary history of L PH.

TL;DR: It is found that signaling through BR3, but not BCMA or TACI, activated the alternative nuclear factor of kappa B (NF-kappaB) pathway in CLL cells, whereas signaling through BCMA/TACI induced activation of the canonical NF- kappaB pathway.

TL;DR: It is reported that aged granulocyte-macrophage colony stimulating factor-deficient mice develop a systemic lupus erythematosis (SLE)-like disorder associated with the impaired phagocytosis of apoptotic cells, demonstrating that the interplay of infectious agents with cytokine-mediated regulation of immune homeostasis is a critical determinant of cancer susceptibility.

TL;DR: Both classical and alternative NF-kappaB signaling are important for development of lupus-like disease associated with BAFF overproduction, and the same mechanisms may be involved in the pathogenesis of human SLE.