BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-κB pathway
Tomoyuki Endo,Mitsufumi Nishio,Thomas Enzler,Howard B. Cottam,Tetsuya Fukuda,Danelle F. James,Michael Karin,Thomas J. Kipps +7 more
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TLDR
It is found that signaling through BR3, but not BCMA or TACI, activated the alternative nuclear factor of kappa B (NF-kappaB) pathway in CLL cells, whereas signaling through BCMA/TACI induced activation of the canonical NF- kappaB pathway.About:
This article is published in Blood.The article was published on 2007-01-15 and is currently open access. It has received 222 citations till now. The article focuses on the topics: B-cell activating factor & B cell.read more
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The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia
Yair Herishanu,Patricia Pérez-Galán,Delong Liu,Angelique Biancotto,Stefania Pittaluga,Berengere Vire,Federica Gibellini,Ndegwa Njuguna,Elinor Lee,Lawrence S. Stennett,Nalini Raghavachari,Poching Liu,J. Philip McCoy,Mark Raffeld,Maryalice Stetler-Stevenson,Constance M. Yuan,Richard M. Sherry,Diane C. Arthur,Irina Maric,Therese White,Gerald E. Marti,Peter J. Munson,Wyndham H. Wilson,Adrian Wiestner +23 more
TL;DR: The disruption of tumor microenvironment interactions and the inhibition of BCR signaling as promising therapeutic strategies in CLL are identified.
Journal ArticleDOI
High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation
Jan A. Burger,Maite P. Quiroga,Elena Hartmann,Andrea Bürkle,William G. Wierda,Michael J. Keating,Andreas Rosenwald +6 more
TL;DR: A novel mechanism of cross talk between CLL cells and their microenvironment is revealed, namely, the secretion of 2 T-cell chemokines in response to NLC coculture and BCR stimulation.
Journal ArticleDOI
Chronic lymphocytic leukaemia.
Thomas J. Kipps,Freda K. Stevenson,Catherine J. Wu,Carlo M. Croce,Graham Packham,William G. Wierda,Susan O'Brien,John G. Gribben,Kanti R. Rai +8 more
TL;DR: Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5+ B cells that is characterized by the accumulation of small, mature-appearing lymphocytes in the blood, marrow and lymphoid tissues as mentioned in this paper.
Journal ArticleDOI
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells
Emanuela Rosati,Rita Sabatini,Giuliana Rampino,Antonio Tabilio,Mauro Di Ianni,Katia Fettucciari,Andrea Bartoli,Stefano Coaccioli,Isabella Screpanti,Pierfrancesco Marconi +9 more
TL;DR: The findings show that Notch signaling plays a critical role in B-CLL cell survival and apoptosis resistance and suggest that it could be a novel potential therapeutic target.
Journal ArticleDOI
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia.
Wan Zhang,Dunyaporn Trachootham,Dunyaporn Trachootham,Jinyun Liu,Gang Chen,Helene Pelicano,Celia Garcia-Prieto,Weiqin Lu,Jan A. Burger,Carlo M. Croce,William Plunkett,Michael J. Keating,Peng Huang +12 more
TL;DR: A biochemical mechanism by which bone marrow stromal cells modulate the redox status of chronic lymphocytic leukaemia (CLL) cells and promote cellular survival and drug resistance is shown.
References
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TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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George A. Calin,Calin Dan Dumitru,Masayoshi Shimizu,Roberta Bichi,Simona Zupo,Evan Noch,Hansjuerg Aldler,Sashi Rattan,Michael J. Keating,Kanti R. Rai,Laura Z. Rassenti,Thomas J. Kipps,Massimo Negrini,Florencia Bullrich,Carlo M. Croce +14 more
TL;DR: Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority (≈68%) of CLL cases.
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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Michael Karin,Yinon Ben-Neriah +1 more
TL;DR: Recent progress has been made in understanding the details of the signaling pathways that regulate NF-kappaB activity, particularly those responding to the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1.
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TL;DR: The authors regret the inability to cite all of the primary literature contributing to this review due to length considerations, but wish to thank F. Chan, T. Migone, and J. Wang for insightful comments on the manuscript.
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