T
Thomas H. Lampe
Researcher at University of Washington
Publications - 23
Citations - 1647
Thomas H. Lampe is an academic researcher from University of Washington. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 16, co-authored 23 publications receiving 1627 citations. Previous affiliations of Thomas H. Lampe include Fred Hutchinson Cancer Research Center & United States Department of Veterans Affairs.
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Journal ArticleDOI
Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease
Gerard D. Schellenberg,Thomas D. Bird,Ellen M. Wijsman,Deborah K. Moore,Michael Boehnke,Eileen Bryant,Eileen Bryant,Thomas H. Lampe,David Nochlin,S. M. Sumi,Samir S. Deeb,Konrad Beyreuther,George M. Martin +12 more
TL;DR: No evidence for linkage was found between familial Alzheimer's disease (FAD) and chromosome 21q21 markers (D 21S1/D21S72 and the amyloid beta gene) and data indicate that FAD is genetically heterogeneous.
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A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L)
Thomas D. Bird,David Nochlin,Parvoneh Poorkaj,Monique M. Cherrier,Jeffrey Kaye,Haydeh Payami,Elaine R. Peskind,Thomas H. Lampe,Ellen Nemens,Philip J. Boyer,Gerard D. Schellenberg +10 more
TL;DR: These three families demonstrate that a missense mutation in the exon 10 microtubule-binding domain of the tau protein gene can produce severe behavioural abnormalities with frontotemporal lobar atrophy and microscopic tau pathology.
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Phenotypic heterogeneity in familial alzheimer's disease: A study of 24 kindreds
Thomas D. Bird,S. M. Sumi,Ellen Nemens,David Nochlin,Gerard D. Schellenberg,Thomas H. Lampe,Thomas H. Lampe,A D Sadovnick,Helena Chang Chui,G. W. Miner,J. Tinklenberg +10 more
TL;DR: The clinical and neuropathological characteristics occurring in 180 demented individuals from 24 kindreds with familial Alzheimer's disease (FAD) are reported and six findings suggested phenotypic heterogeneity in FAD.
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Familial Alzheimer's disease in American descendants of the Volga Germans: probable genetic founder effect.
TL;DR: Five families are described in which autopsy‐confirmed presenile Alzheimer's disease (AD) has occurred in men and women over multiple generations consistent with autosomal dominant inheritance, and it is likely that the AD in these families represents an autosome dominant gene inherited from one ancestor (the founder effect).
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Myoclonus, seizures, and paratonia in Alzheimer disease.
Steven C. Risse,Thomas H. Lampe,Thomas D. Bird,David Nochlin,S. M. Sumi,Trisha Keenan,Lyndel Cubberley,Elaine R. Peskind,Murray A. Raskind +8 more
TL;DR: The incidence of myoclonus, seizures, and paratonia in patients with the clinical diagnosis of probable Alzheimer disease was higher than in most previous studies; the reasons for this finding are discussed.