Deborah K. Moore

TL;DR: No evidence for linkage was found between familial Alzheimer's disease (FAD) and chromosome 21q21 markers (D 21S1/D21S72 and the amyloid beta gene) and data indicate that FAD is genetically heterogeneous.

TL;DR: An association between the F allele of apolipoprotein CII and familial Alzheimer's disease is suggested and LOD scores summed for the complete group of families were negative and close linkage was excluded.

TL;DR: It is highly unlikely that a chromosome 21 gene is responsible for late-onset FAD and at least some forms of early-onsett FAD represented by the Volga German kindreds.

TL;DR: This article uses statistical shape analysis with deformation markers obtained through “Large Deformation Diffeomorphic Metric Mapping” of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease.

TL;DR: Investigation of additional late-onset AD genes will require larger samples, more sophisticated analysis methods, and large-scale positional cloning efforts, with the strongest evidence being for chromosome 12.