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Thomas J. Greshock
Researcher at Colorado State University
Publications - 40
Citations - 1360
Thomas J. Greshock is an academic researcher from Colorado State University. The author has contributed to research in topics: Total synthesis & Indole test. The author has an hindex of 18, co-authored 36 publications receiving 1265 citations. Previous affiliations of Thomas J. Greshock include University of Colorado Boulder & University of Colorado Denver.
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Journal ArticleDOI
Isolation, Structure Elucidation, and Biomimetic Total Synthesis of Versicolamide B, and the Isolation of Antipodal ()-Stephacidin A and (+)-Notoamide B from Aspergillus versicolor NRRL 35600**
Thomas J. Greshock,Alan W. Grubbs,Ping Jiao,Donald T. Wicklow,Donald T. Wicklow,James B. Gloer,Robert M. Williams +6 more
TL;DR: The isolation, structure elucidation, and confirmatory biomimetic total synthesis of the first member of the paraherquamide-stephacidin family to possess the rare anti-relative stereochemistry within the bicyclo-diazaoctane ring system are described.
Journal ArticleDOI
Synthesis and Conformation-Activity Relationships of the Peptide Isosteres of FK228 and Largazole
Albert A. Bowers,Thomas J. Greshock,Nathan West,Guillermina Estiu,Stuart L. Schreiber,Olaf Wiest,Robert M. Williams,James Elliot Bradner +7 more
TL;DR: The peptide isosteres (10 and 11) of the naturally occurring and potent histone deacetylase (HDAC) inhibitors FK228 and largazole have been synthesized and evaluated side-by-side with FK 228, largazoles, and SAHA for inhibition of the class I HDACs 1, 2, 3, and 6.
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Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived aspergillus sp.
Yousong Ding,Jeffrey R. de Wet,James D. Cavalcoli,Shengying Li,Thomas J. Greshock,Thomas J. Greshock,Kenneth A. Miller,Kenneth A. Miller,Jennifer M. Finefield,Jennifer M. Finefield,James D. Sunderhaus,James D. Sunderhaus,Timothy J. McAfoos,Timothy J. McAfoos,Sachiko Tsukamoto,Robert M. Williams,Robert M. Williams,David H. Sherman +17 more
TL;DR: The results establish the early steps for creation of the prenylated indole alkaloid structure and suggest a scheme for the biosynthesis of stephacidin and notoamide metabolites, providing the first genetic and biochemical insights for understanding the structural diversity of this important family of fungal alkaloids.
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Isolation of antipodal (-)-versicolamide B and notoamides L-N from a marine-derived Aspergillus sp
Sachiko Tsukamoto,Tetsuro Kawabata,Hikaru Kato,Thomas J. Greshock,Hiroshi Hirota,Tomihisa Ohta,Robert M. Williams +6 more
TL;DR: The possible biosynthetic pathway of enantiomeric pairs of notoamide B and versicolamide B are proposed and Notoamide L is the first metabolite containing 25 carbons in the related prenylated indole alkaloids.