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Thomas J. Hiscox
Researcher at Monash University, Clayton campus
Publications - 11
Citations - 490
Thomas J. Hiscox is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: Clostridium perfringens & Mutant. The author has an hindex of 7, co-authored 10 publications receiving 448 citations. Previous affiliations of Thomas J. Hiscox include Monash University.
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Journal ArticleDOI
Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens
Garry S. A. Myers,David A. Rasko,David A. Rasko,Jackie K. Cheung,Jacques Ravel,Rekha Seshadri,Robert T. DeBoy,Qinghu Ren,John J. Varga,Milena M. Awad,Lauren M. Brinkac,Sean C. Daugherty,Daniel H. Haft,Robert J. Dodson,Ramana Madupu,William C. Nelson,M. J. Rosovitz,Steven A. Sullivan,Hoda Khouri,George Dimitrov,Kisha Watkins,Stephanie Mulligan,Jonathan L. Benton,Diana Radune,Derek J. Fisher,Helen S. Atkins,Thomas J. Hiscox,B. Helen Jost,Stephen J. Billington,J. Glenn Songer,Bruce A. McClane,Richard W. Titball,Julian I. Rood,Stephen B. Melville,Ian T. Paulsen +34 more
TL;DR: Significant differences between the strains include numerous novel mobile elements and genes encoding metabolic capabilities, strain-specific extracellular polysaccharide capsule, sporulation factors, toxins, and other secreted enzymes, providing substantial insight into this medically important bacterial pathogen.
Journal ArticleDOI
Detection of an en masse and reversible B- to A-DNA conformational transition in prokaryotes in response to desiccation
Donna R. Whelan,Thomas J. Hiscox,Julian I. Rood,Keith R. Bambery,Keith R. Bambery,Donald McNaughton,Bayden R. Wood +6 more
TL;DR: This work reports the first direct observation of a fully reversible en masse conformational transition between B- and A-DNA within live bacterial cells using Fourier transform infrared (FTIR) spectroscopy.
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Regulation of Virulence by the RevR Response Regulator in Clostridium perfringens
Thomas J. Hiscox,Anjana Chakravorty,Jocelyn M. Choo,Kaori Ohtani,Tohru Shimizu,Jackie K. Cheung,Julian I. Rood +6 more
TL;DR: Evidence is provided that RevR regulates virulence in C. perfringens; it is the first response regulator other than VirR to be shown to regulatevirulence in this important pathogen.
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Cross-complementation of Clostridium perfringens PLC and Clostridium septicum α-toxin mutants reveals PLC is sufficient to mediate gas gangrene
Catherine Kennedy,Dena Lyras,Jackie K. Cheung,Thomas J. Hiscox,John J. Emmins,Julian I. Rood +5 more
TL;DR: A reciprocal complementation approach was used to assess the contribution of the primary toxin of each species to disease and found that C. perfringens alpha-toxin was able to mediate the gross pathology of myonecrosis even in a C. septicum background, although it could not induce vascular leukostasis.
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The Pore-Forming α-Toxin from Clostridium septicum Activates the MAPK Pathway in a Ras-c-Raf-Dependent and Independent Manner
Anjana Chakravorty,Milena M. Awad,Jackie K T Cheung,Thomas J. Hiscox,Dena Lyras,Julian I. Rood +5 more
TL;DR: In the mouse myonecrosis model, it was shown that the MAPK pathway was activated in tissues of infected mice, implying that it has an important role in the disease process.