J
John J. Varga
Researcher at Emory University
Publications - 26
Citations - 1825
John J. Varga is an academic researcher from Emory University. The author has contributed to research in topics: Clostridium perfringens & Microbiome. The author has an hindex of 16, co-authored 25 publications receiving 1665 citations. Previous affiliations of John J. Varga include J. Craig Venter Institute & George Washington University.
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Journal ArticleDOI
Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens
Garry S. A. Myers,David A. Rasko,David A. Rasko,Jackie K. Cheung,Jacques Ravel,Rekha Seshadri,Robert T. DeBoy,Qinghu Ren,John J. Varga,Milena M. Awad,Lauren M. Brinkac,Sean C. Daugherty,Daniel H. Haft,Robert J. Dodson,Ramana Madupu,William C. Nelson,M. J. Rosovitz,Steven A. Sullivan,Hoda Khouri,George Dimitrov,Kisha Watkins,Stephanie Mulligan,Jonathan L. Benton,Diana Radune,Derek J. Fisher,Helen S. Atkins,Thomas J. Hiscox,B. Helen Jost,Stephen J. Billington,J. Glenn Songer,Bruce A. McClane,Richard W. Titball,Julian I. Rood,Stephen B. Melville,Ian T. Paulsen +34 more
TL;DR: Significant differences between the strains include numerous novel mobile elements and genes encoding metabolic capabilities, strain-specific extracellular polysaccharide capsule, sporulation factors, toxins, and other secreted enzymes, providing substantial insight into this medically important bacterial pathogen.
Journal ArticleDOI
HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.
Markus Schrettl,Nicola Beckmann,John J. Varga,Thorsten Heinekamp,Ilse D. Jacobsen,Christoph Jöchl,Tarek A. A. Moussa,Shaohua Wang,Fabio Gsaller,Michael Blatzer,Ernst R. Werner,William C. Niermann,Axel A. Brakhage,Hubertus Haas +13 more
TL;DR: In this paper, the bZIP-type regulator HapX is indispensable for the transcriptional remodeling required for adaption to iron starvation in the opportunistic fungal pathogen Aspergillus fumigatus.
Journal Article
HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus RID F-4349-2010
TL;DR: It is demonstrated that HapX-dependent adaption to conditions of iron starvation is crucial for virulence of A. fumigatus, a opportunistic fungal pathogen facing iron starvation in the host.
Journal ArticleDOI
Type IV pili‐dependent gliding motility in the Gram‐positive pathogen Clostridium perfringens and other Clostridia
John J. Varga,Van Nguyen,David K. O'Brien,Katherine Rodgers,R. A. Walker,Stephen B. Melville +5 more
TL;DR: It is shown that C.’perfringens produces TFP and moves with an unusual form of gliding motility involving groups of densely packed cells moving away from the edge of a colony in curvilinear flares, and it is demonstrated that Clostridium beijerinckii can move via glider motility.
Journal ArticleDOI
Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis
Breck A. Duerkop,John J. Varga,Josephine R. Chandler,Snow Brook Peterson,Jake P. Herman,Mair E. A. Churchill,Matthew R. Parsek,William C. Nierman,E. Peter Greenberg +8 more
TL;DR: Stationary-phase cultures of wild-type B. thailandensis produced an antibiotic effective against gram-positive bacteria, and the nature of the signals produced by one of the systems, BtaR2-BtaI2, was determined, and it was shown that this system controls genes required for the synthesis of an antibiotic.