T
Thomas Powles
Researcher at Queen Mary University of London
Publications - 804
Citations - 57482
Thomas Powles is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 82, co-authored 655 publications receiving 39271 citations. Previous affiliations of Thomas Powles include Charing Cross Hospital & University of London.
Papers
More filters
Journal ArticleDOI
Molecular determinants of response to PD-L1 blockade across tumor types.
Romain Banchereau,Ning Leng,Oliver A. Zill,Ethan Sokol,Gengbo Liu,Dean Pavlick,Sophia Maund,Li-Fen Liu,Edward E. Kadel,Nicole Baldwin,Suchit Jhunjhunwala,Dorothee Nickles,Zoe June Assaf,Daniel Bower,Namrata Patil,Mark McCleland,David S. Shames,Luciana Molinero,Mahrukh Huseni,Shomyseh Sanjabi,Craig Cummings,Ira Mellman,Sanjeev Mariathasan,Priti Hegde,Thomas Powles +24 more
TL;DR: In this article, a cross-indication analysis reveals molecular heterogeneity between mUC, NSCLC and RCC tumors, suggesting that indication-specific molecular approaches should be prioritized to formulate treatment strategies.
Journal ArticleDOI
Does HIV adversely influence the outcome in advanced non-small-cell lung cancer in the era of HAART?
Thomas Powles,C Thirwell,T. Newsom-Davis,Mark T. Nelson,Pallav L. Shah,Sarah Cox,Brian Gazzard,Mark Bower +7 more
TL;DR: The survival of patients with HIV-related NSCLC may have improved since the introduction of HAART, and this may be due to a decrease in HIV- related deaths.
Journal ArticleDOI
Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial
Daniel P. Petrylak,Ronald de Wit,Kim N. Chi,Alexandra Drakaki,Cora N. Sternberg,Hiroyuki Nishiyama,Daniel Castellano,Syed A. Hussain,Aude Flechon,Aristotelis Bamias,Evan Y. Yu,Michiel S. van der Heijden,Nobuaki Matsubara,Boris Alekseev,Andrea Necchi,Lajos Géczi,Yen Chuan Ou,Hasan Şenol Coşkun,Wen Pin Su,Jens Bedke,Georgios Gakis,Georgios Gakis,Ivor J. Percent,Jae-Lyun Lee,Marcello Tucci,Andrey Semenov,Fredrik Laestadius,Avivit Peer,Giampaolo Tortora,Sufia Safina,Xavier Garcia del Muro,Alejo Rodriguez-Vida,Irfan Cicin,Hakan Harputluoglu,Scott T. Tagawa,Ulka N. Vaishampayan,Jeanny B. Aragon-Ching,Oday Hamid,Astra M. Liepa,Sameera R. Wijayawardana,Francesca Russo,Richard A. Walgren,Annamaria Zimmermann,Rebecca R. Hozak,Katherine M Bell-McGuinn,Thomas Powles,Suet Lai Shirley Wong,Thean Hsiang Tan,Elizabeth Jane Hovey,Timothy Dudley Clay,Siobhan Ng,Annemie Rutten,Jean-Pascal Machiels,Herlinde Dumez,Susanna Yee Shan Cheng,Cristiano Ferrario,Lisa Sengeloev,Niels Viggo Jensen,Constance Thibault,Brigitte Laguerre,Florence Joly,Stéphane Culine,Catherine Becht,Günter Niegisch,Michael Stöckle,Marc-Oliver Grimm,Christina A. Schwentner,Wolfgang Schultze-Seemann,Haralambos Kalofonos,Dimitrios Mavroudis,Christos Papandreou,Vasilis Karavasilis,János Révész,Eli Rosenbaum,Raya Leibowitz-Amit,Daniel Kejzman,David Sarid,Giorgio V. Scagliotti,Sergio Bracarda,Francesco Massari,Takahiro Osawa,Naoto Miyajima,Nobuo Shinohara,Fumimasa Fukuta,Chikara Ohyama,Wataru Obara,Shinichi Yamashita,Yoshihiko Tomita,Koji Kawai,Satoshi Fukasawa,Masafumi Oyama,Junji Yonese,Masayoshi Nagata,Motohide Uemura,Kazuo Nishimura,Mutsushi Kawakita,Hiroyuki Tsunemori,Katsuyoshi Hashine,Junichi Inokuchi,Akira Yokomizo,Satoshi Nagamori,Hyo Jin Lee,Se Hoon Park,Sun Young Rha,Yu Jung Kim,Yun Gyoo Lee,Leticia Vazquez Cortés,Claudia Lorena Urzua Flores,Reinoud J. B. Blaisse,Fransiscus L.G. Erdkamp,Maureen J.B. Aarts,Joanna Wojcik-Tomaszewska,Piotr Tomczak,Bozena Sikora-Kupis,Michael Schenker,Alina Amalia Herzal,Anghel Adrian Udrea,Petr Alexandrovich Karlov,Roman Fomkin,Pablo Gajate Borau,Enrique Grande,Juan Ignacio Delgado Mignorance,Yu Li Su,Jian Ri Li,Chien Liang Lin,Chia-Chi Lin,Su Peng Yeh,Mustafa Erman,Yuksel Urun,Yuriy Golovko,Igor Bondarenko,Ivan Sinielnikov,Simon J. Crabb,Isabel Syndikus,Robert Huddart,Santhanam Sundar,Simon Chowdhury,Naveed Sarwar,Thomas W. Flaig,Chong-Xian Pan,James K. Schwarz,Jennifer L. Cultrera,Peter Istvan Acs,John D. Hainsworth,Benjamin T. Herms,William E. Lawler,Thomas Eugene Lowe +146 more
TL;DR: Additional follow-up supports that ramucirumab plus docetaxel significantly improves progression-free survival, without a significant improvement in overall survival, for patients with platinum-refractory advanced urothelial carcinoma.
Journal ArticleDOI
The evolving role of PD-L1 testing in patients with metastatic urothelial carcinoma.
TL;DR: PD-L1 testing provides enriched information on the patients most likely to benefit from immune checkpoint blockade and should be routinely offered to patients with metastatic UC.
Journal ArticleDOI
Hepatocellular carcinoma, human immunodeficiency virus and viral hepatitis in the HAART era
TL;DR: It has yet to be clearly established whether HIV directly accelerates HCC pathogenesis or whether the rising incidence is an epiphenomenon of the highly active antiretroviral therapy (HAART) era, wherein the increased longevity of patients with HIV allows long-term complications of viral hepatitis and cirrhosis to develop.