T
Thomas S. Scerri
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 45
Citations - 3888
Thomas S. Scerri is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Dyslexia & DCDC2. The author has an hindex of 28, co-authored 45 publications receiving 3324 citations. Previous affiliations of Thomas S. Scerri include University of Melbourne & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Association of the KIAA0319 dyslexia susceptibility gene with reading skills in the general population.
Silvia Paracchini,Colin D Steer,Lyn-Louise Buckingham,Andrew P. Morris,Susan M. Ring,Thomas S. Scerri,John F. Stein,Marcus Pembrey,Jiannis Ragoussis,Jean Golding,Anthony P. Monaco +10 more
TL;DR: A role of the KIAA0319 gene in the development of dyslexia is supported and the data implicate the three-SNP haplotype and its tagging SNP rs2143340 as genetic risk factors for poor reading performance.
Journal ArticleDOI
Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia
Alistair T. Pagnamenta,Elena Bacchelli,Maretha de Jonge,Ghazala Mirza,Thomas S. Scerri,Fiorella Minopoli,Andreas G. Chiocchetti,Kerstin U. Ludwig,Per Hoffmann,Silvia Paracchini,Ernesto Lowy,Denise Harold,Jade Chapman,Sabine M. Klauck,Fritz Poustka,Renske H. Houben,Wouter G. Staal,Roel A. Ophoff,Roel A. Ophoff,Michael Conlon O'Donovan,Julie Williams,Markus M. Nöthen,Gerd Schulte-Körne,Panos Deloukas,Jiannis Ragoussis,Anthony J. Bailey,Elena Maestrini,Anthony P. Monaco +27 more
TL;DR: This study highlights two new risk factors for ASD and dyslexia and demonstrates the importance of performing a high-resolution assessment of genomic background, even after detection of a rare and likely damaging microdeletion using a targeted approach.
Journal ArticleDOI
High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.
Elena Maestrini,Alistair T. Pagnamenta,Janine A. Lamb,Janine A. Lamb,Elena Bacchelli,Nuala Sykes,Inês Sousa,Claudio Toma,Gabrielle Barnby,H Butler,Laura Winchester,Thomas S. Scerri,Fiorella Minopoli,Jennifer Reichert,Guiqing Cai,Joseph D. Buxbaum,O Korvatska,Gerard D. Schellenberg,Geraldine Dawson,Geraldine Dawson,A de Bildt,Ruud B. Minderaa,Erik J. Mulder,Andrew P. Morris,Anthony J. Bailey,Anthony P. Monaco +25 more
TL;DR: A high-density association analysis in AUTS1 and AUTS5, testing more than 3000 single nucleotide polymorphisms in all known genes in each region, as well as SNPs in non-genic highly conserved sequences highlighted several genes that warrant further investigation.
Journal ArticleDOI
PCSK6 is associated with handedness in individuals with dyslexia
Thomas S. Scerri,William M. Brandler,Silvia Paracchini,Andrew P. Morris,Susan M. Ring,Alex J. Richardson,Joel B. Talcott,John F. Stein,Anthony P. Monaco +8 more
TL;DR: The results provide molecular evidence that cerebral asymmetry and dyslexia are linked, and functional studies of PCSK6 promise insights into mechanisms underlying cerebral lateralization and Dyslexia.
Journal ArticleDOI
A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development
Else Eising,Amaia Carrion-Castillo,Arianna Vino,Edythe A. Strand,Kathy J. Jakielski,Thomas S. Scerri,Thomas S. Scerri,Michael S. Hildebrand,Richard Webster,Alan Ma,Bernard Mazoyer,Clyde Francks,Clyde Francks,Melanie Bahlo,Melanie Bahlo,Ingrid E. Scheffer,Ingrid E. Scheffer,Angela T Morgan,Lawrence D. Shriberg,Simon E. Fisher,Simon E. Fisher +20 more
TL;DR: This study sequenced whole genomes of nineteen unrelated individuals diagnosed with childhood apraxia of speech and identified novel loss-of-function variants affecting KAT6A, SETBP1, ZFHX4, TNRC6B and MKL2, regulatory genes with links to neurodevelopment.