T
Thomas Simmet
Researcher at University of Ulm
Publications - 211
Citations - 15559
Thomas Simmet is an academic researcher from University of Ulm. The author has contributed to research in topics: Proinflammatory cytokine & Monocyte. The author has an hindex of 54, co-authored 202 publications receiving 13691 citations. Previous affiliations of Thomas Simmet include University of Freiburg & French Institute of Health and Medical Research.
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Journal ArticleDOI
11-Keto-α-Boswellic Acid, a Novel Triterpenoid from Boswellia spp. with Chemotaxonomic Potential and Antitumor Activity against Triple-Negative Breast Cancer Cells.
Michael Schmiech,Judith Ulrich,Sophia J. Lang,Berthold Büchele,Christian Paetz,Alexis St-Gelais,Tatiana Syrovets,Thomas Simmet +7 more
TL;DR: In this paper, the existence and natural occurrence of the respective α-isomer, 11-keto-α-boswellic acid (α-KBA), is demonstrated for the first time.
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STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1α/VEGF signaling pathway
Yang Liu,Konrad Steinestel,Arefeh Rouhi,Milena Armacki,Kristina Diepold,Gabriela Chiosis,Thomas Simmet,Thomas Seufferlein,Ninel Azoitei +8 more
TL;DR: It is reported that elevated STK33 expression correlates with advanced stages of human pancreatic and colorectal carcinomas and interferes with signals from hypoxia and HSP90 to promote tumor angiogenesis and tumor growth.
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Evidence for the formation of endothelin by lysed red blood cells from endogenous precursor
TL;DR: Human as well as rat blood cell fractions can also liberate the direct vasoconstrictor, endothelin, a finding expected to be of considerable pathophysiological significance.
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High-Contrast Magnetic Resonance Imaging and Efficient Delivery of an Albumin Nanotheranostic in Triple-Negative Breast Cancer Xenografts
Susanne Hafner,Marco Raabe,Marco Raabe,Yuzhou Wu,Yuzhou Wu,Tao Wang,Zhi Zuo,Volker Rasche,Tatiana Syrovets,Tanja Weil,Tanja Weil,Thomas Simmet +11 more
TL;DR: The biodegradable albumin‐based nanocarriers reveal high‐contrast tumor imaging and efficient drug delivery in a preclinical TNBC xenograft model, where the xenografteds are grown on the chorioallantoic membrane of fertilized chick eggs.
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Thrombin Stimulates Activation of the Cerebral 5-Lipoxygenase Pathway during Blood-Brain Cell Contact:
TL;DR: It is demonstrated that, in rats, during blood–brain cell contact, stimulation of the 5-lipoxygenase pathway in brain cells proceeds via α-thrombin as effector molecule.