Thomas Simmet

TL;DR: Downregulation of each of the receptor subunits by antisense oligodeoxynucleotides abolished the plasmin-induced expression of proinflammatory cytokines stressing the crucial role the annexin A2 heterotetramer.

TL;DR: Data indicate that nanosized superparamagnetic iron oxide-based contrast media exert cytotoxicity in human macrophages that can be functionally antagonized with radical scavengers.

TL;DR: A mathematical model of the uptake process of diagnostically used carboxydextran-coated superparamagnetic iron oxide nanoparticles of 60 nm (SPIO) and 20 nm (USPIO) by human macrophages is developed and a new physical parameter 'a' governing the collective uptake process is introduced, a reflecting minimal linear spacing between simultaneously acting neighboring endocytotic pits.

TL;DR: It is demonstrated that human plasmacytoid dendritic cells can be an abundant source of GrB and that such GrB(+) pDCs potently suppress T-cell proliferation in a GrB-dependent, perforin-independent manner, a process reminiscent of regulatory T cells.

TL;DR: This article evaluated the effect of arglabin on the NLRP3 inflammasome inhibition and atherosclerotic lesion in ApoE2Ki mice fed a high-fat Western-type diet.