T
Thomas Simmet
Researcher at University of Ulm
Publications - 211
Citations - 15559
Thomas Simmet is an academic researcher from University of Ulm. The author has contributed to research in topics: Proinflammatory cytokine & Monocyte. The author has an hindex of 54, co-authored 202 publications receiving 13691 citations. Previous affiliations of Thomas Simmet include University of Freiburg & French Institute of Health and Medical Research.
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Journal ArticleDOI
Ethosomes and lipid-coated chitosan nanocarriers for skin delivery of a chlorophyll derivative: A potential treatment of squamous cell carcinoma by photodynamic therapy.
Soad Nasr,Mai Rady,Iman Gomaa,Tatiana Syrovets,Thomas Simmet,Walid Fayad,Mahmoud H. Abdel-Kader +6 more
TL;DR: Both types of nanocarriers can be used for their potential treatment of SCC using PDT depending on the tumour localization in the skin.
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Cellular mechanism of fibril formation from serum amyloid A1 protein
Stephanie Claus,Katrin Meinhardt,Tobias Aumüller,Ioana Puscalau-Girtu,Julia Linder,Christian Haupt,Paul Walther,Tatiana Syrovets,Thomas Simmet,Marcus Fändrich +9 more
TL;DR: It is shown that HDL binding blocks fibril formation from soluble SAA1 protein, whereas internalization into mononuclear phagocytes leads to the formation of amyloid.
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Peroxisome proliferator-activated receptor gamma induces apoptosis and inhibits autophagy of human monocyte-derived macrophages via induction of cathepsin L: potential role in atherosclerosis.
Dler Faieeq Darweesh Mahmood,Imene Jguirim-Souissi,El-Hadri Khadija,Nicolas Blondeau,Vimala Diderot,Souliman Amrani,Mohamed-Naceur Slimane,Tatiana Syrovets,Thomas Simmet,Mustapha Rouis +9 more
TL;DR: The data show that PPARγ can specifically induce CatL, a proatherogenic protease, in HMDM, which could be neutralized by apoptosis, a beneficial phenomenon, at least in the early stages of atherosclerosis.
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Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet—A Randomized Controlled Trial in Healthy Participants
Ann-Kathrin Lederer,Luciana Hannibal,Manuel Hettich,Sidney Behringer,Ute Spiekerkoetter,Carmen Steinborn,Carsten Gründemann,Amy Marisa Zimmermann-Klemd,Alexander Müller,Thomas Simmet,Michael Schmiech,Andrea Maul-Pavicic,Yvonne Samstag,Roman Huber +13 more
TL;DR: Plasma holo-TC may be a fast-responding biomarker to monitor adequate supply of vitamin B12 in plant-based individuals to reduce the risk of micronutrient deficiencies in Vegans.
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Inhibition of the Inflammasome NLRP3 by Arglabin Attenuates Inflammation, Protects Pancreatic β-Cells from Apoptosis, and Prevents Type 2 Diabetes Mellitus Development in ApoE2Ki Mice on a Chronic High-Fat Diet.
Amna Abderrazak,Khadija El Hadri,Elodie Bosc,Bertrand Blondeau,Mohamed-Naceur Slimane,Berthold Büchele,Thomas Simmet,Dominique Couchie,Mustapha Rouis +8 more
TL;DR: In this paper, an intraitoneal injection of arglabin (2.5 ng/g of body weight, twice daily, 13 weeks) into female human apolipoprotein E2 gene knock-in (ApoE2Ki) mice fed a high-fat Western-type diet (HFD) reduced plasma levels of glucose and insulin by ∼20.0% ± 3.5% and by 50.0%.