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Thomas Simmet

Researcher at University of Ulm

Publications -  211
Citations -  15559

Thomas Simmet is an academic researcher from University of Ulm. The author has contributed to research in topics: Proinflammatory cytokine & Monocyte. The author has an hindex of 54, co-authored 202 publications receiving 13691 citations. Previous affiliations of Thomas Simmet include University of Freiburg & French Institute of Health and Medical Research.

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Journal ArticleDOI

Overexpression of Phospholipid-hydroperoxide Glutathione Peroxidase in Human Dermal Fibroblasts Abrogates UVA Irradiation-induced Expression of Interstitial Collagenase/Matrix Metalloproteinase-1 by Suppression of Phosphatidylcholine Hydroperoxide-mediated NFκB Activation and Interleukin-6 Release

Jutta Wenk, +18 more
- 29 Oct 2004 - 
TL;DR: UVA irradiation-induced PCOOHs and subsequent lipid peroxides initiate the NFκB-mediated induction of IL-6, which mediates the induction of MMP-1, and this finding is particularly relevant in light of the already available small molecule mimetics of PHGPx.
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Tirucallic Acids Are Novel Pleckstrin Homology Domain-Dependent Akt Inhibitors Inducing Apoptosis in Prostate Cancer Cells

Aydee Constanza Estrada, +8 more
- 01 Mar 2010 - 
TL;DR: The tirucallic acid derivatives represent a new class of Akt inhibitors with antitumor properties that inhibited proliferation and induced apoptosis in tumors xenografted onto chick chorioallantoic membranes and decreased the growth of pre-established prostate tumors in nude mice without overt systemic toxicity.
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Nanoparticle interactions with live cells: Quantitative fluorescence microscopy of nanoparticle size effects.

Li Shang, +7 more
- 11 Dec 2014 - 
TL;DR: This work systematically analyzed the cellular uptake of fluorescent NPs in the size range of 3.3–100 nm (diameter) by live cells and attributed this distinct size dependence to the requirement of a sufficiently strong local interaction of the NPs with the endocytic machinery in order to trigger the subsequent internalization.
Journal Article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2459 more
- 01 Jan 2016 - 
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EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction

Peter Seizer, +14 more
- 13 Mar 2009 - 
TL;DR: In this article, platelet glycoprotein VI (GPVI) was identified as a novel adhesion receptor for EMMPRIN, which can mediate platelet rolling via GPVI-EMMPRIN interaction.