T
Thomas Simmet
Researcher at University of Ulm
Publications - 211
Citations - 15559
Thomas Simmet is an academic researcher from University of Ulm. The author has contributed to research in topics: Proinflammatory cytokine & Monocyte. The author has an hindex of 54, co-authored 202 publications receiving 13691 citations. Previous affiliations of Thomas Simmet include University of Freiburg & French Institute of Health and Medical Research.
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Journal ArticleDOI
Oleanolic acid methyl ester, a novel cytotoxic mitocan, induces cell cycle arrest and ROS-Mediated cell death in castration-resistant prostate cancer PC-3 cells.
Noha Abdelmageed,Samy A.F. Morad,Samy A.F. Morad,Ashraf A. El-Ghoneimy,Tatiana Syrovets,Thomas Simmet,Hesham El-zorba,Hossney A. El-Banna,Myles C. Cabot,Magdy I. Abdel-Aziz +9 more
TL;DR: In vivo, OAME exerted concentration- dependent antiproliferative effect, associated with a significant level of apoptosis, potent antiangiogenic activity, and downregulation of survivin, suggesting that OAME might serve as a promising lead compound to treat hormonal-resistant prostate cancer.
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Hexon Modification to Improve the Activity of Oncolytic Adenovirus Vectors against Neoplastic and Stromal Cells in Pancreatic Cancer
Tanja Lucas,Karim Benihoud,Frédéric Vigant,Christoph Q. Schmidt,Max G. Bachem,Thomas Simmet,Stefan Kochanek +6 more
TL;DR: To increase activity of replicating Ad vectors, it is proposed to relax tumor cell selectivity by genetic hexon-mediated targeting to the TGFBR to enable replication also in the stromal cell compartment of tumors, while abolishing hepatocyte transduction, and thereby increasing safety.
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Requirement for YAP1 signaling in myxoid liposarcoma
Marcel Trautmann,Ya-Yun Cheng,Ya-Yun Cheng,Patrizia Jensen,Patrizia Jensen,Ninel Azoitei,Ines Brunner,Jennifer Hüllein,Jennifer Hüllein,Mikolaj Slabicki,Ilka Isfort,Magdalene Cyra,Ruth Berthold,Eva Wardelmann,Sebastian Huss,Bianca Altvater,Claudia Rossig,Claudia Rossig,Susanne Hafner,Thomas Simmet,Anders Ståhlberg,Anders Ståhlberg,Pierre Åman,Thorsten Zenz,Thorsten Zenz,Undine Lange,Thomas Kindler,Claudia Scholl,Wolfgang Hartmann,Stefan Fröhling +29 more
TL;DR: It is shown that FUS‐DDIT3‐expressing mesenchymal stem cells and MLS cell lines are dependent on Yap1, a transcriptional co‐activator and central effector of the Hippo pathway involved in tissue growth and tumorigenesis, and that increased YAP1 activity is a hallmark of human MLS.
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Acetyl-lupeolic acid inhibits Akt signaling and induces apoptosis in chemoresistant prostate cancer cells in vitro and in vivo
Claudia Schmidt,Cornelia Loos,Lu Jin,Michael Schmiech,Christoph Q. Schmidt,Menna El Gaafary,Menna El Gaafary,Tatiana Syrovets,Thomas Simmet +8 more
TL;DR: Ac-LA exhibited antiproliferative, proapoptotic, and antitumorigenic effects on PC-3-tumors xenografted either on chick chorioallantoic membranes or in nude mice, and exhibited a clearly better safety profile than docetaxel or lupeol during chronic administration in vivo.
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B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21
Magdalena Hagn,Sue E. Blackwell,Thamara Beyer,Verena Ebel,Dorit Fabricius,Stefanie Lindner,S. Stilgenbauer,Thomas Simmet,Constantine S. Tam,Paul J Neeson,Joseph A. Trapani,Hubert Schrezenmeier,George J. Weiner,Bernd Jahrsdörfer +13 more
TL;DR: It is demonstrated that treatment of B-CLL cells with CpG and IL-21 results in the development of antigen-presenting cell (APC)-like cells with cytotoxic features, which result in enhanced immunogenicity, cytotoxicity and apoptosis.