T
Thomas Simmet
Researcher at University of Ulm
Publications - 211
Citations - 15559
Thomas Simmet is an academic researcher from University of Ulm. The author has contributed to research in topics: Proinflammatory cytokine & Monocyte. The author has an hindex of 54, co-authored 202 publications receiving 13691 citations. Previous affiliations of Thomas Simmet include University of Freiburg & French Institute of Health and Medical Research.
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The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways.
TL;DR: In this paper, the authors demonstrate that plasmin stimulates mitogen-activated protein kinase (MAPK) signaling via phosphorylation of MAPK kinase 3/6 (MKK3/6) and p38 MAPK that triggers subsequent DNA binding of transcription factor activator protein-1 (AP-1).
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Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKbeta-mediated NF-kappaB activation.
Tatiana Syrovets,Marina Jendrach,Marina Jendrach,Angela Rohwedder,Angela Rohwedder,Almut Schüle,Almut Schüle,Thomas Simmet,Thomas Simmet +8 more
TL;DR: The role of plasmin as a proinflammatory activator of human monocytes is substantiated and an important new link between the plasmineogen-plasmin system and inflammation is revealed.
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Targeting XIAP Bypasses Bcl-2–Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo
Meike Vogler,Henning Walczak,Dominic Stadel,Tobias L. Haas,Felicitas Genze,Marjana Jovanovic,Jürgen E. Gschwend,Thomas Simmet,Klaus-Michael Debatin,Simone Fulda +9 more
TL;DR: The combination of X-linked inhibitor of apoptosis (XIAP) inhibition and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an effective approach to trigger apoptosis despite Bcl-2 overexpression and to suppress pancreatic cancer growth in vitro and in vivo.
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Inhibition of IκB Kinase Activity by Acetyl-boswellic Acids Promotes Apoptosis in Androgen-independent PC-3 Prostate Cancer Cells in Vitro and in Vivo
Tatiana Syrovets,Jürgen E. Gschwend,Berthold Büchele,Yves Laumonnier,Waltraud Zugmaier,Felicitas Genze,Thomas Simmet +6 more
TL;DR: AKβBA and related compounds acting on IKK might provide a novel approach for the treatment of chemoresistant human tumors such as androgen-independent PC-3 prostate cancer cells in vitro and in vivo.
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Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma
Meike Vogler,Henning Walczak,Dominic Stadel,Tobias L. Haas,Felicitas Genze,Marjana Jovanovic,Umesh Bhanot,Cornelia Hasel,Peter Møller,Juergen E. Gschwend,Thomas Simmet,Klaus-Michael Debatin,Simone Fulda +12 more
TL;DR: Findings provide, for the first time, evidence in vivo that XIAP inhibitors prime pancreatic carcinoma cells for TRAIL-induced apoptosis and potentiate the antitumor activity of TRAIL against established pancreatic cancer.