T
Thomas Simmet
Researcher at University of Ulm
Publications - 211
Citations - 15559
Thomas Simmet is an academic researcher from University of Ulm. The author has contributed to research in topics: Proinflammatory cytokine & Monocyte. The author has an hindex of 54, co-authored 202 publications receiving 13691 citations. Previous affiliations of Thomas Simmet include University of Freiburg & French Institute of Health and Medical Research.
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Journal ArticleDOI
The Cardenolide Glycoside Acovenoside A Affords Protective Activity in Doxorubicin-Induced Cardiotoxicity in Mice.
Shahira M. Ezzat,Menna El Gaafary,Abeer M. El Sayed,Omar M. Sabry,Zeinab Y. Ali,Susanne Hafner,Michael Schmiech,Lu Jin,Tatiana Syrovets,Thomas Simmet +9 more
TL;DR: Cardenolide glycoside A might act as a cardioprotective agent to prevent doxorubicin-induced cardiotoxicity as indicated by normalization of the levels of different myocardial markers of oxidative stress, serum myocardIAL diagnostic marker enzymes, and inflammatory markers.
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Characterization of cysteinyl-leukotriene formation in primary astroglial cell cultures.
TL;DR: The results show that astrocytes may contribute to brain LTC4 and LTD4 synthesis, however, the cellular site of cerebral LTE4 formation seems to be other than the astroglia.
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High-performance liquid chromatographic determination of acetyl-11-keto-α-boswellic acid, a novel pentacyclic triterpenoid, in plasma using a fluorinated stationary phase and photodiode array detection : Application in pharmacokinetic studies
TL;DR: In this paper, a rapid, sensitive and selective HPLC separation with photodiode array detection was developed for the analysis of the novel pentacyclic triterpenoid acetyl-11-keto-α-boswellic acid.
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Characterization of seizure-induced cysteinyl-leukotriene formation in brain tissue of convulsion-prone gerbils.
TL;DR: The results demonstrate formation of cysteinyl‐LT following tonicclonic convulsions in spontaneously convulsing gerbils which could be enhanced by inhibition of the cyclooxygenase pathway of arachidonic acid metabolism.
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An α-Acetoxy-Tirucallic Acid Isomer Inhibits Akt/mTOR Signaling and Induces Oxidative Stress in Prostate Cancer Cells
TL;DR: The ability of αATA(8,24) to inhibit Akt/mTOR signaling and to induce simultaneously oxidative stress could be exploited for the development of novel antitumor therapeutics with a lower profile of toxic side effects.