T
Thomas von Zglinicki
Researcher at Newcastle University
Publications - 194
Citations - 26368
Thomas von Zglinicki is an academic researcher from Newcastle University. The author has contributed to research in topics: Senescence & Telomere. The author has an hindex of 70, co-authored 183 publications receiving 21927 citations. Previous affiliations of Thomas von Zglinicki include Charité & Humboldt State University.
Papers
More filters
Journal ArticleDOI
Mitochondrial dysfunction in cell senescence and aging
TL;DR: The potential of senescence-associated mitochondrial dysfunction is highlighted as an antiaging and antisenescence intervention target, and the combination of multiple interventions converging onto mitochondrial dysfunction as novel, potent senolytics is proposed.
Journal ArticleDOI
Accelerated telomere shortening in Fanconi anemia fibroblasts--a longitudinal study.
Caroline Adelfalk,Mario Lorenz,Violeta Serra,Thomas von Zglinicki,Monica Hirsch-Kauffmann,Manfred Schweiger +5 more
TL;DR: In a longitudinal study, it is demonstrated that telomeric DNA is continuously lost at a higher rate in FA fibroblasts compared to healthy controls and that this loss is caused rather by an increased shortening per cell division in regularly replicating cells than by apoptosis.
Journal ArticleDOI
Science fact and the SENS agenda
Huber R. Warner,Julie Anderson,Steven N. Austad,Ettore Bergamini,Dale E. Bredesen,Robert N. Butler,Bruce A. Carnes,Brian F.C. Clark,Vincent J. Cristofalo,John A. Faulkner,Leonard Guarente,David E. Harrison,Thomas B. L. Kirkwood,Gordon J. Lithgow,George M. Martin,Ed Masoro,Simon Melov,Richard A. Miller,S. Jay Olshansky,Linda Partridge,Olivia M. Pereira-Smith,Thomas T. Perls,Arlan Richardson,James R. Smith,Thomas von Zglinicki,Eugenia Wang,Jeanne Y. Wei,T. Franklin Williams +27 more
TL;DR: In an article published in the EMBO reports Special Issue on Time and Ageing, Aubrey D. de Grey criticizes biogerontologists for what he sees as their generally pessimistic view of the possibilities for intervening in the ageing process.
Journal ArticleDOI
Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver
S. Verma,Phaedra M. Tachtatzis,Sue Penrhyn-Lowe,Cinzia G. Scarpini,Diana Jurk,Thomas von Zglinicki,Nicholas Coleman,Graeme J.M. Alexander +7 more
TL;DR: In normal liver and over a broad age range, cholangiocytes have longer telomeres than all other intrahepatic lineages and age‐related telomere length decline is restricted to Kupffer cells and stellate cells.
Journal ArticleDOI
Inflammation, telomere length, and grip strength: a 10-year longitudinal study.
D. Baylis,D. Baylis,Georgia Ntani,Mark H. Edwards,Holly E. Syddall,David B. Bartlett,Elaine M. Dennison,Carmen Martin-Ruiz,Thomas von Zglinicki,Diana Kuh,Janet M. Lord,Avan Aihie Sayer,Avan Aihie Sayer,Cyrus Cooper,Cyrus Cooper +14 more
TL;DR: Evidence is presented that inflammaging may be driving telomere attrition and in part explains the associations that have previously been reported between TL and grip strength, which means biomarkers of physical aging may require greater exploration.