T
Tim Wharton
Researcher at Massachusetts Institute of Technology
Publications - 12
Citations - 1187
Tim Wharton is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Photodynamic therapy & Photosensitizer. The author has an hindex of 9, co-authored 12 publications receiving 1070 citations.
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Journal ArticleDOI
Photodynamic therapy with fullerenes
Pawel Mroz,George P. Tegos,Hariprasad Gali,Tim Wharton,Tadeusz Sarna,Michael R. Hamblin,Michael R. Hamblin +6 more
TL;DR: Fullerenes are a class of closed-cage nanomaterials made exclusively from carbon atoms that absorb visible light, have a high triplet yield and can generate reactive oxygen species upon illumination, suggesting a possible role of fullerene in photodynamic therapy.
Journal ArticleDOI
Cationic Fullerenes Are Effective and Selective Antimicrobial Photosensitizers
George P. Tegos,Tatiana N. Demidova,Tatiana N. Demidova,Dennisse Arcila-Lopez,Haeryeon Lee,Tim Wharton,Hariprasad Gali,Michael R. Hamblin,Michael R. Hamblin +8 more
TL;DR: Six functionalized C(60) compounds with one, two, or three hydrophilic or cationic groups in combination with white light against gram-positive bacteria, gram-negative bacteria, and fungi are compared.
Journal ArticleDOI
Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism.
Pawel Mroz,Anna Pawlak,Minahil Satti,Haeryeon Lee,Tim Wharton,Hariprasad Gali,Tadeusz Sarna,Michael R. Hamblin,Michael R. Hamblin +8 more
TL;DR: It is concluded that certain functionalized fullerenes have potential as novel PDT agents and phototoxicity may be mediated both by superoxide and by singlet oxygen.
Journal ArticleDOI
Photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections.
Zongshun Lu,Tianhong Dai,Liyi Huang,Liyi Huang,Divya Balachandran Kurup,George P. Tegos,George P. Tegos,Ashlee A. Jahnke,Tim Wharton,Michael R. Hamblin +9 more
TL;DR: It is suggested that cationic fullerenes have clinical potential as an antimicrobial photosensitizer for superficial infections where red light is not needed to penetrate tissue.
Journal ArticleDOI
Innovative cationic fullerenes as broad-spectrum light-activated antimicrobials.
Liyi Huang,Mitsuhiro Terakawa,Mitsuhiro Terakawa,Timur Zhiyentayev,Timur Zhiyentayev,Ying-Ying Huang,Ying-Ying Huang,Yohei Sawayama,Yohei Sawayama,Ashlee A. Jahnke,George P. Tegos,Tim Wharton,Michael R. Hamblin,Michael R. Hamblin +13 more
TL;DR: Several new cationic fullerenes are presented in this paper, and their efficacy against Gram-positive, Gram-negative bacteria, and a fungal yeast is also demonstrated.