T
Tom Conlin
Researcher at Oregon Health & Science University
Publications - 14
Citations - 2154
Tom Conlin is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Zebrafish Information Network genome database & Zebrafish Model Organism Database. The author has an hindex of 11, co-authored 14 publications receiving 1753 citations. Previous affiliations of Tom Conlin include University of Oregon & University of Colorado Boulder.
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Journal ArticleDOI
Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources
Sebastian Köhler,Leigh C. Carmody,Nicole Vasilevsky,Julius O.B. Jacobsen,Daniel Danis,Jean-Philippe F. Gourdine,Michael A. Gargano,Nomi L. Harris,Nicolas Matentzoglu,Julie A. McMurry,David Osumi-Sutherland,Valentina Cipriani,James P. Balhoff,Tom Conlin,Hannah Blau,Gareth Baynam,Richard Palmer,Dylan Gratian,Hugh Dawkins,Michael M. Segal,Anna Jansen,Ahmed Muaz,Willie H. Chang,Jenna R.E. Bergerson,Stanley J. F. Laulederkind,Zafer Yüksel,Sergi Beltran,Alexandra F. Freeman,Panagiotis I. Sergouniotis,Daniel Durkin,Andrea L. Storm,Marc Hanauer,Michael Brudno,Susan M. Bello,Murat Sincan,Kayli Rageth,Matthew T. Wheeler,Renske Oegema,Halima Lourghi,Maria G. Della Rocca,Rachel Thompson,Francisco Castellanos,James R. Priest,Charlotte Cunningham-Rundles,Ayushi Hegde,Ruth C. Lovering,Catherine Hajek,Annie Olry,Luigi D. Notarangelo,Morgan Similuk,Xingmin Aaron Zhang,David Gómez-Andrés,Hanns Lochmüller,Hélène Dollfus,Sergio Rosenzweig,Shruti Marwaha,Ana Rath,Kathleen E. Sullivan,Cynthia L. Smith,Joshua D. Milner,Dorothée Leroux,Cornelius F. Boerkoel,Amy D. Klion,Melody C. Carter,Tudor Groza,Damian Smedley,Melissa A. Haendel,Melissa A. Haendel,Christopher J. Mungall,Peter N. Robinson +69 more
TL;DR: The HPO’s interoperability with other ontologies has enabled it to be used to improve diagnostic accuracy by incorporating model organism data and plays a key role in the popular Exomiser tool, which identifies potential disease-causing variants from whole-exome or whole-genome sequencing data.
Journal ArticleDOI
The Zebrafish Information Network: the zebrafish model organism database
Judy Sprague,Leyla Bayraktaroglu,Dave Clements,Tom Conlin,David Fashena,Ken Frazer,Melissa A. Haendel,Douglas G. Howe,Prita Mani,Sridhar Ramachandran,Kevin Schaper,Erik Segerdell,Peiran Song,Brock Sprunger,Sierra Taylor,Ceri E. Van Slyke,Monte Westerfield +16 more
TL;DR: The Zebrafish Information Network (ZFIN) provides an integrated representation of mutants, genes, genetic markers, mapping panels, publications and community resources such as meeting announcements and contact information.
Journal ArticleDOI
The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species.
Christopher J. Mungall,Julie A. McMurry,Sebastian Köhler,James P. Balhoff,Charles D. Borromeo,Matthew H. Brush,Seth Carbon,Tom Conlin,Nathan Dunn,Mark Engelstad,Erin D. Foster,Jean-Philippe F. Gourdine,Julius O.B. Jacobsen,Daniel Keith,Bryan Laraway,Suzanna E. Lewis,Jeremy Nguyen-Xuan,Kent Shefchek,Nicole Vasilevsky,Zhou Yuan,Nicole L. Washington,Harry Hochheiser,Tudor Groza,Damian Smedley,Peter N. Robinson,Melissa A. Haendel +25 more
TL;DR: The Monarch Initiative as discussed by the authors integrates information on genes, variants, genotypes, phenotypes and diseases in a variety of species, and allows powerful ontology-based search, and develops many widely adopted ontologies that together enable sophisticated computational analysis, mechanistic discovery and diagnostics of Mendelian diseases.
Journal ArticleDOI
ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics
Douglas G. Howe,Yvonne M. Bradford,Tom Conlin,Anne E. Eagle,David Fashena,Ken Frazer,Jonathan Knight,Prita Mani,Ryan Martin,Sierra A. T. Moxon,Holly Paddock,Christian Pich,Sridhar Ramachandran,Barbara J. Ruef,Leyla Ruzicka,Kevin Schaper,Xiang Shao,Amy Singer,Brock Sprunger,Ceri E. Van Slyke,Monte Westerfield +20 more
TL;DR: Recent enhancements to ZFIN aimed at improving support for mutant and transgenic lines are described, including enhanced mutant/transgenic search functionality, more expressive phenotype curation methods, and incorporation of new data loads from laboratories undertaking large-scale generation of mutant or transgenic Lines.
Journal ArticleDOI
ZFIN: enhancements and updates to the Zebrafish Model Organism Database.
Yvonne M. Bradford,Tom Conlin,Nathan Dunn,David Fashena,Ken Frazer,Douglas G. Howe,Jonathan Knight,Prita Mani,Ryan Martin,Sierra A. T. Moxon,Holly Paddock,Christian Pich,Sridhar Ramachandran,Barbara J. Ruef,Leyla Ruzicka,Holle A. Bauer Schaper,Kevin Schaper,Xiang Shao,Amy Singer,Judy Sprague,Brock Sprunger,Ceri E. Van Slyke,Monte Westerfield +22 more
TL;DR: Recent additions to ZFIN are described including (i) enhanced access to images, (ii) genomic features, (iii) genome browser, (iv) transcripts, (v) antibodies and a community wiki for protocols and antibodies.