T
Tomasz M. Wróbel
Researcher at Medical University of Lublin
Publications - 34
Citations - 203
Tomasz M. Wróbel is an academic researcher from Medical University of Lublin. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 6, co-authored 20 publications receiving 117 citations. Previous affiliations of Tomasz M. Wróbel include University of Copenhagen.
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Journal ArticleDOI
Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics
Mie Fabricius Pedersen,Tomasz M. Wróbel,Emil Märcher-Rørsted,Daniel Sejer Pedersen,Thor C. Møller,Federica Gabriele,Henrik Pedersen,Dariusz Matosiuk,Simon R. Foster,Michel Bouvier,Hans Bräuner-Osborne +10 more
TL;DR: The data reveal that the clinically available drug buprenorphine displays a similar pharmacological bias profile in vitro compared to the clinical candidate drug oliceridine and that this bias is independent of binding kinetics suggesting a mechanism driven by receptor-conformations.
Journal ArticleDOI
Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs
Magda Kondej,Tomasz M. Wróbel,Andrea G. Silva,Piotr Stępnicki,Oliwia Koszła,Ewa Kędzierska,Agata Bartyzel,Grazyna Biala,Dariusz Matosiuk,María Isabel Loza,Marián Castro,Agnieszka A. Kaczor,Agnieszka A. Kaczor +12 more
TL;DR: 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles (1-20) which are ligands of dopamine D2 and serotonin 5-HT1A and 5- HT2A receptors and display affinity in the nanomolar range are presented.
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Experimental and computational studies on the tautomerism of N-substituted 3-amino-5-oxo-4-phenyl-1H-pyrazolo-1-carboxamides with antibacterial activity
Agnieszka A. Kaczor,Agnieszka A. Kaczor,Tomasz M. Wróbel,Zbigniew Karczmarzyk,Waldemar Wysocki,Ewaryst Mendyk,Antti Poso,Dariusz Matosiuk,Monika Pitucha +8 more
TL;DR: The tautomerism of 3-amino-5-oxo-4-phenyl-1H-pyrazolo-1-carboxamides with antibacterial activity was studied with X-ray crystallography, IR, 1H and 13C NMR and quantum chemical calculations as mentioned in this paper.
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Discovery of nitroaryl urea derivatives with antiproliferative properties.
Tomasz M. Wróbel,Michał Kiełbus,Agnieszka A. Kaczor,Vladimír Kryštof,Zbigniew Karczmarzyk,Waldemar Wysocki,Andrzej Fruziński,Sylwia K Król,Aneta Grabarska,Andrzej Stepulak,Dariusz Matosiuk +10 more
TL;DR: A series of urea derivatives bearing nitroaryl moiety has been synthesized and assayed for their potential antiproliferative activities and generally demonstrated greater cytotoxicity in comparison to cisplatin.
Journal ArticleDOI
Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D2 Receptor Ligand
Magda Kondej,Agata Bartyzel,Monika Pitucha,Tomasz M. Wróbel,Tomasz M. Wróbel,Andrea G. Silva,Dariusz Matosiuk,Marián Castro,Agnieszka A. Kaczor,Agnieszka A. Kaczor +9 more
TL;DR: The studied compound is characterized by good thermal stability and was docked to the novel X-ray structure of the human dopamine D2 receptor in the inactive state and established the main contact between its protonatable nitrogen atom and Asp (3.32) of the receptor.