V
Vitaly A. Selivanov
Researcher at University of Barcelona
Publications - 46
Citations - 1717
Vitaly A. Selivanov is an academic researcher from University of Barcelona. The author has contributed to research in topics: Metabolic flux analysis & Workflow. The author has an hindex of 18, co-authored 45 publications receiving 1475 citations. Previous affiliations of Vitaly A. Selivanov include Russian Academy of Sciences & Moscow State University.
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Journal ArticleDOI
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
Joanna Kaplon,Liang Zheng,Katrin Meissl,Barbara Chaneton,Vitaly A. Selivanov,Gillian M. Mackay,Sjoerd H. van der Burg,Elizabeth M. E. Verdegaal,Marta Cascante,Tomer Shlomi,Tomer Shlomi,Eyal Gottlieb,Daniel S. Peeper +12 more
TL;DR: It is shown that the mitochondrial gatekeeper pyruvate dehydrogenase (PDH) is a crucial mediator of senescence induced by BRAFV600E, an oncogene commonly mutated in melanoma and other cancers, and a mechanistic relationship between OIS and a key metabolic signalling axis is revealed, which may be exploited therapeutically.
Journal ArticleDOI
Reactive Oxygen Species Production by Forward and Reverse Electron Fluxes in the Mitochondrial Respiratory Chain
Vitaly A. Selivanov,Tatyana V. Votyakova,Violetta N. Pivtoraiko,Jennifer A. Zeak,Tatiana Sukhomlin,Massimo Trucco,Josep Roca,Marta Cascante +7 more
TL;DR: The rule-based model of complex III was extended to account for electron transport in the whole RC coupled to proton translocation, transmembrane electrochemical potential generation, TCA cycle reactions, and substrate transport to mitochondria and revealed an association of ROS production with levels of specific radicals of individual electron transporters and their combinations in species of complexes I and III.
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PhenoMeNal: processing and analysis of metabolomics data in the cloud
Kristian Peters,James Bradbury,Sven Bergmann,Sven Bergmann,Marco Capuccini,Marta Cascante,Pedro de Atauri,Timothy M. D. Ebbels,Carles Foguet,Robert C. Glen,Robert C. Glen,Alejandra Gonzalez-Beltran,Ulrich L. Günther,Evangelos Handakas,Thomas Hankemeier,Kenneth Haug,Stephanie Herman,Petr Holub,Massimiliano Izzo,Daniel J. Jacob,David Johnson,David Johnson,Fabien Jourdan,Namrata Kale,Ibrahim Karaman,Bita Khalili,Bita Khalili,Payam Emami Khoonsari,Kim Kultima,Samuel Lampa,Anders Larsson,Christian Ludwig,Pablo Moreno,Steffen Neumann,Jon Ander Novella,Claire O'Donovan,Jake T M Pearce,Alina Peluso,Marco Enrico Piras,Luca Pireddu,Michelle A.C. Reed,Philippe Rocca-Serra,Pierrick Roger,Antonio Rosato,Rico Rueedi,Rico Rueedi,Christoph Ruttkies,Noureddin Sadawi,Noureddin Sadawi,Reza M. Salek,Susanna-Assunta Sansone,Vitaly A. Selivanov,Ola Spjuth,Daniel Schober,Etienne A. Thévenot,Mattia Tomasoni,Mattia Tomasoni,Merlijn van Rijswijk,Michael van Vliet,Mark R. Viant,Ralf J. M. Weber,Gianluigi Zanetti,Christoph Steinbeck +62 more
TL;DR: PhenoMeNal is an advanced and complete solution to set up Infrastructure-as-a-Service (IaaS) that brings workflow-oriented, interoperable metabolomics data analysis platforms into the cloud and constitutes a keystone solution in cloud e-infrastructures available for metabolomics.
Journal ArticleDOI
The Role of External and Matrix pH in Mitochondrial Reactive Oxygen Species Generation
Vitaly A. Selivanov,Jennifer A. Zeak,Josep Roca,Marta Cascante,Massimo Trucco,Tatyana V. Votyakova +5 more
TL;DR: It is found that high pH strongly increased the rate of free radical generation in all of the conditions studied, even when ΔpH = 0 in the presence of nigericin.
Journal ArticleDOI
Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program.
Esther Aguilar,Igor Marín de Mas,Erika Zodda,Silvia Marin,Fionnuala Morrish,Vitaly A. Selivanov,Óscar Meca-Cortés,Hossain Delowar,Mònica Pons,Inés Izquierdo,Toni Celià-Terrassa,Pedro de Atauri,Josep J. Centelles,David M. Hockenbery,Timothy M. Thomson,Marta Cascante +15 more
TL;DR: It is found that the e‐CSC program in this cellular model is characterized by a high plasticity in energy substrate metabolism, including an enhanced Warburg effect, a greater carbon and energy source flexibility driven by fatty acids and amino acid metabolism and an essential reliance on the proton buffering capacity conferred by glutamine metabolism.