Tomonori Takeuchi

TL;DR: It is found that the hippocampal-dependent learning of new paired associates is associated with a striking up-regulation of immediate early genes in the prelimbic region of the medial prefrontal cortex, and that pharmacological interventions targeted at that area can prevent both new learning and the recall of remotely and even recently consolidated information.

TL;DR: For example, this paper found that the locus coeruleus is especially sensitive to environmental novelty and locus co-activation of TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in the hippocampus.

TL;DR: Evidence derived using optical imaging, molecular-genetic and optogenetic techniques in conjunction with appropriate behavioural analyses continues to offer support for the idea that changing the strength of connections between neurons is one of the major mechanisms by which engrams are stored in the brain.

TL;DR: It is suggested that GluRdelta2 mediates cerebellar synapse formation by interacting with presynaptic NRXNs through Cbln1.

TL;DR: It is proposed that the projections originating from the VTA and the LC belong to two distinct systems that enhance memory of novel events, which include experiences that share some commonality with past experiences and experiences that bear only a minimal relationship to past experiences.