T
Tomoya O. Akama
Researcher at Kansai Medical University
Publications - 65
Citations - 2119
Tomoya O. Akama is an academic researcher from Kansai Medical University. The author has contributed to research in topics: Keratan sulfate & Macular corneal dystrophy. The author has an hindex of 24, co-authored 59 publications receiving 1915 citations. Previous affiliations of Tomoya O. Akama include Kansai University & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene.
Tomoya O. Akama,Kohji Nishida,Kohji Nishida,Jun Nakayama,Jun Nakayama,Hitoshi Watanabe,Kouichi Ozaki,Takahiro Nakamura,Atsuyoshi Dota,Satoshi Kawasaki,Yoshitsugu Inoue,Naoyuki Maeda,Shuji Yamamoto,Tsutomu Fujiwara,Eugene J.-M.A. Thonar,Yoshikazu Shimomura,Shigeru Kinoshita,Akira Tanigami,Michiko N. Fukuda +18 more
TL;DR: A new carbohydrate sulphotransferase gene (CHST6), encoding an enzyme designated corneal N-acetylglucosamine-6-sulphotranferase (C-GlcNAc6ST), is identified within the critical region of MCD type I, suggesting that mutations found in type II lead to loss of cornea-specific expression of CHST6.
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Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase
Masahito Horiguchi,Tadashi Inoue,Tetsuya Ohbayashi,Maretoshi Hirai,Kazuo Noda,Kazuo Noda,Lihua Y. Marmorstein,Daisuke Yabe,Kyoko Takagi,Tomoya O. Akama,Toru Kita,Takeshi Kimura,Tomoyuki Nakamura +12 more
TL;DR: A dose-dependent requirement for FBLN4 in the development of the elastic fibers in arteries, and a specific role of FBLn4 in recruiting the elastin-cross-linking enzyme, lysyl oxidase (LOX), suggest a mechanism of elastogenesis, in which a sufficient amount of FblN4 is essential for tethering LOX to tropoelastin to facilitate cross-l linking.
Journal ArticleDOI
Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.
Tomoya O. Akama,Hiroaki Nakagawa,Kazuhiro Sugihara,Sonoko Narisawa,Chikara Ohyama,Shin-Ichiro Nishimura,Deborah A. O'Brien,Kelley W. Moremen,José Luis Millán,Michiko N. Fukuda +9 more
TL;DR: It is demonstrated that targeted disruption of Man2a2, a gene encoding α-mannosidase IIx (MX), an enzyme that forms intermediate asparagine-linked carbohydrates (N-glycans), results in Man 2a2 null males that are largely infertile.
Journal ArticleDOI
Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family.
Nobuyoshi Hiraoka,Hiroaki Nakagawa,Edgar O. Ong,Tomoya O. Akama,Michiko N. Fukuda,Minoru Fukuda +5 more
TL;DR: Northern analysis demonstrated that the transcript for C4 ST-1 is predominantly expressed in peripheral leukocytes and hematopoietic tissues while theC4ST-2 transcript is more widely expressed in various tissues, indicating C4STs play complementary roles in chondroitin and dermatan sulfate synthesis in different tissues.
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Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.
Kazuo Noda,Branka Dabovic,Kyoko Takagi,Tadashi Inoue,Masahito Horiguchi,Maretoshi Hirai,Yusuke Fujikawa,Tomoya O. Akama,Kenji Kusumoto,Lior Zilberberg,Lynn Y. Sakai,Katri Koli,Motoko Naitoh,Harald von Melchner,Shigehiko Suzuki,Daniel B. Rifkin,Tomoyuki Nakamura +16 more
TL;DR: It is shown that latent TGF-β binding protein 4 (LTBP-4) potentiates formation of elastic fibers through interacting with fibulin-5, a tropoelastin-binding protein necessary for elastogenesis.