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Beat Nyfeler

Researcher at Novartis

Publications -  30
Citations -  8114

Beat Nyfeler is an academic researcher from Novartis. The author has contributed to research in topics: Endoplasmic reticulum & Autophagy. The author has an hindex of 21, co-authored 30 publications receiving 6672 citations. Previous affiliations of Beat Nyfeler include University of Basel.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

Paul Nicklin, +16 more
- 06 Feb 2009 - 
TL;DR: It is shown that cellular uptake of L-glutamine and its subsequent rapid efflux in the presence of essential amino acids (EAA) is the rate-limiting step that activates mTOR.
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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, +46 more
- 01 Nov 2014 - 
TL;DR: a4−/− mice exhibit a profound accumulation of iron in splenic macrophages, which are critical for the reutilization of iron from engulfed red blood cells, and a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo is revealed.
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Capturing protein interactions in the secretory pathway of living cells.

Beat Nyfeler, +2 more
- 03 May 2005 - 
TL;DR: YFP PCA can detect weak and transient protein interactions in the secretory pathway and hence is a powerful approach to study luminal processes involved in protein secretion, and is extended to carbohydrate-mediated protein-protein interactions of low affinity.
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Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

Christina H. Eng, +19 more
- 05 Jan 2016 - 
TL;DR: Data indicate that KRAS mutation status does not predict cell-autonomous addiction to autophagy, and addresses a long-standing question regarding the mechanism of chloroquine, a lysosomotropic agent often used as a pharmacological tool to evaluate the response to macroautophagy inhibition.