T
Toshiro Moroishi
Researcher at Kumamoto University
Publications - 42
Citations - 5206
Toshiro Moroishi is an academic researcher from Kumamoto University. The author has contributed to research in topics: Hippo signaling pathway & Tissue homeostasis. The author has an hindex of 18, co-authored 37 publications receiving 3828 citations. Previous affiliations of Toshiro Moroishi include University of California, San Diego & Kyushu University.
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Journal ArticleDOI
Mechanisms of Hippo pathway regulation
TL;DR: This review focuses on recent developments in the understanding of the molecular actions of the core Hippo kinase cascade and discusses key open questions in the regulation and function of the Hippo pathway.
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The emerging roles of YAP and TAZ in cancer
TL;DR: The current understanding of the biological functions of YAP and TAZ is summarized, and how the regulation of these two proteins can be disrupted in cancer is described.
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Alternative Wnt Signaling Activates YAP/TAZ
Hyun Woo Park,Young Chul Kim,Bo Yu,Toshiro Moroishi,Jung-Soon Mo,Steven W. Plouffe,Zhipeng Meng,Kimberly C. Lin,Fa-Xing Yu,Caroline M. Alexander,Cun-Yu Wang,Kun-Liang Guan +11 more
TL;DR: This work establishes YAP/TAZ as critical mediators of alternative Wnt signaling, including gene expression, osteogenic differentiation, cell migration, and antagonism of Wnt/β-catenin signaling.
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YAP and TAZ: a nexus for Hippo signaling and beyond.
TL;DR: The function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ) and their role as a signaling nexus and integrator of several other prominent signaling pathways such as the Wnt, G protein-coupled receptor (GPCR), epidermal growth factor (EGF), bone morphogenetic protein (BMP)/transforming growth factor beta, and Notch pathways are discussed.
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MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
Zhipeng Meng,Toshiro Moroishi,Violaine Mottier-Pavie,Steven W. Plouffe,Carsten G. Hansen,Audrey W. Hong,Hyun Woo Park,Jung-Soon Mo,Wenqi Lu,Shicong Lu,Fabian Flores,Fa-Xing Yu,Georg Halder,Kun-Liang Guan +13 more
TL;DR: It is demonstrated that MAP4Ks act in parallel to and are partially redundant with MST1/2 in the regulation of LATS 1/2 and YAP/TAZ, and this work establishes MAP 4Ks as components of the expanded Hippo pathway.