F
F.A. Boop
Researcher at St. Jude Children's Research Hospital
Publications - 19
Citations - 1711
F.A. Boop is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Pilocytic astrocytoma & Astrocytoma. The author has an hindex of 9, co-authored 19 publications receiving 1438 citations. Previous affiliations of F.A. Boop include Murphy Oil & Boston Children's Hospital.
Papers
More filters
Journal ArticleDOI
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
Jinghui Zhang,Gang Wu,Claudia P. Miller,Ruth G. Tatevossian,James Dalton,Bo Tang,Wilda Orisme,Chandanamali Punchihewa,Matthew Parker,Ibrahim Qaddoumi,F.A. Boop,Charles Lu,Cyriac Kandoth,Li Ding,Ryan P. Lee,Robert Huether,Xiang Chen,Erin Hedlund,Panduka Nagahawatte,Michael Rusch,Kristy Boggs,Jinjun Cheng,Jared Becksfort,Jing Ma,Guangchun Song,Yongjin Li,Lei Wei,Jianmin Wang,Sheila A. Shurtleff,John Easton,David Zhao,Robert S. Fulton,Lucinda Fulton,David J. Dooling,Bhavin Vadodaria,Heather L. Mulder,Chunlao Tang,Kerri Ochoa,Charles G. Mullighan,Amar Gajjar,Richard W. Kriwacki,Denise Sheer,Richard J. Gilbertson,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Suzanne J. Baker,David W. Ellison +47 more
TL;DR: Focusing on the therapeutically challenging diffuse LGGs, this study of 151 tumors has discovered genetic alterations and potential therapeutic targets across the entire range of pediatric L GGs and LGGNTs.
Journal ArticleDOI
Cross-species genomics matches driver mutations and cell compartments to model ependymoma
Robert A. Johnson,Karen Wright,Helen Poppleton,Kumarasamypet M. Mohankumar,David Finkelstein,Stanley Pounds,Vikki Rand,Sarah Leary,Elsie White,Christopher J. Eden,Twala L. Hogg,Paul A. Northcott,Stephen C. Mack,Geoffrey Neale,Yong Dong Wang,Beth Coyle,Jennifer M. Atkinson,Mariko DeWire,Tanya A. Kranenburg,Yancey Gillespie,Jeffrey C. Allen,Thomas E. Merchant,F.A. Boop,Robert A. Sanford,Amar Gajjar,David W. Ellison,Michael D. Taylor,Richard Grundy,Richard J. Gilbertson +28 more
TL;DR: Comparison of matched mouse and human tumours revealed selective deregulation in the expression and copy number of genes that control synaptogenesis, pinpointing disruption of this pathway as a critical event in the production of this ependymoma subgroup.
Journal ArticleDOI
Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology
Ibrahim Qaddoumi,Wilda Orisme,Ji Wen,Teresa Santiago,Kirti Gupta,James Dalton,Bo Tang,Kelly Haupfear,Chandanamali Punchihewa,John Easton,Heather L. Mulder,Kristy Boggs,Ying Shao,Michael Rusch,Jared Becksfort,Pankaj Gupta,Shuoguo Wang,Ryan P. Lee,Daniel J. Brat,V. Peter Collins,Sonika Dahiya,David George,William Konomos,Kathreena M Kurian,Kathryn McFadden,Luciano Neder Serafini,Hilary Highfield Nickols,Arie Perry,Sheila A. Shurtleff,Amar Gajjar,F.A. Boop,Paul Klimo,Elaine R. Mardis,Richard K. Wilson,Suzanne J. Baker,Jinghui Zhang,Gang Wu,James R. Downing,Ruth G. Tatevossian,David W. Ellison +39 more
TL;DR: Altered genes in BRAF, FGFR1, or MYB account for most pathogenic alterations in LGNTs, including pilocytic astrocytomas, and alignment of these genetic alterations and cytologic features acrossLGNTs has diagnostic implications.
Journal ArticleDOI
Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.
Kristian W. Pajtler,Kristian W. Pajtler,Ji Wen,Martin Sill,Tong Lin,Wilda Orisme,Bo Tang,Jens-Martin Hübner,Vijay Ramaswamy,Sujuan Jia,James Dalton,Kelly Haupfear,Hazel A. Rogers,Chandanamali Punchihewa,Ryan P. Lee,John Easton,Gang Wu,Timothy A Ritzmann,Rebecca Chapman,Lukas Chavez,F.A. Boop,Paul Klimo,Noah D. Sabin,Robert J. Ogg,Stephen C. Mack,Stephen C. Mack,Brian D. Freibaum,Hong Joo Kim,Hendrik Witt,Hendrik Witt,David T.W. Jones,BaoHan T. Vo,Amar Gajjar,Stan Pounds,Arzu Onar-Thomas,Martine F. Roussel,Jinghui Zhang,J. Paul Taylor,J. Paul Taylor,Thomas E. Merchant,Richard Grundy,Ruth G. Tatevossian,Michael D. Taylor,Stefan M. Pfister,Stefan M. Pfister,Andrey Korshunov,Andrey Korshunov,Marcel Kool,David W. Ellison +48 more
TL;DR: DNA methylation profiling and transcriptome profiling suggest that heterogeneity among PFA ependymomas could have clinicopathologic utility and that CXorf67 may have a functional role in these tumors.
Journal ArticleDOI
Distinct disease-risk groups in pediatric supratentorial and posterior fossa ependymomas
Catherine Godfraind,Joanna M. Kaczmarska,Mehmet Kocak,James Dalton,Karen Wright,Robert A. Sanford,F.A. Boop,Amar J. Gajjar,Thomas E. Merchant,David W. Ellison +9 more
TL;DR: Among children developing posterior fossa ependymomas treated with maximal surgical resection and conformal radiotherapy, key clinicopathological variables and chromosome 1q status can be used to define tiers of disease risk.